ID   BOP1_LEIIN              Reviewed;         808 AA.
AC   A4HUV2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=LinJ11.0410, LinJ_11_0410;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FR796443; CAM66213.1; -; Genomic_DNA.
DR   RefSeq; XP_001463843.1; XM_001463806.1.
DR   AlphaFoldDB; A4HUV2; -.
DR   SMR; A4HUV2; -.
DR   STRING; 5671.XP_001463843.1; -.
DR   GeneID; 5067219; -.
DR   KEGG; lif:LINJ_11_0410; -.
DR   VEuPathDB; TriTrypDB:LINF_110009000; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   InParanoid; A4HUV2; -.
DR   OMA; MRPAKGE; -.
DR   Proteomes; UP000008153; Chromosome 11.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..808
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370411"
FT   REPEAT          430..469
FT                   /note="WD 1"
FT   REPEAT          640..680
FT                   /note="WD 2"
FT   REPEAT          682..720
FT                   /note="WD 3"
FT   REPEAT          724..766
FT                   /note="WD 4"
FT   REPEAT          777..808
FT                   /note="WD 5"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  91356 MW;  22150FB788A6E19D CRC64;
     MTSPKGKPSP KRSAPAPTTA ALTPRTEERT EGATSSASAS ASSHISSSFD SPRDDTVVFT
     GYTAESKHNA HGYERLHDII LQDGDTGADS EDGRANEDNV ILFPHAEELA NAAAGINGDD
     DNGRVVRLGT IQHLEESDSS EDEPTLNRVG DIPLEWYKDE DHIGYDIEGK KLMKKERSAL
     ERLLEATDDP NAMRTIYDAL HDEKKTLSNA DLQLIFNLQR NRTTNPNYDM YSEVQEDTVV
     FDPLNHPLAR SGGPSKRAFV PALHDMKVIA KMVRRLRKEE AERKLRPGKE EKEEEDQLLW
     DDGHVEMDTH THFKYFNRVP KPKLPPPGTF ESYRPPPEYL PSERAKQRQA RLRAIDRKEH
     FLPQSFDALR HVPFYHHTIQ DRYQRCLDLA FFPRAQRTRL VVDPDKLLPE LPDPKDLRPY
     PEKLSFHYKG HTATVRSVSV SPNGQYLATG CDDHLVRVFE VQTGRLMKRY DMGAPVQQVE
     FCPSTSLNIL AAAVEYSLVF IVPTFAAHTL VNDHTIRFLR APGLSAGQRE AAHALGAVDT
     LGGRAVTQTT LDADETAHEA TADLHDIEER EKRAEFVDAS AKERNAGIVV KIAMHAKVKK
     FCFHIKGDYL CALCPKDHVK YRQTIMLQLS KRKVFCPFRK FSEVVTDCRF HPREPIFFLA
     TTNSVRCYNL MAHRLQRRFK ASGGVTTCLS IHPEGDNFLV GDTTSHTSWF DMDFSDKPYK
     RMRSHRGVVN ALAFHPKTNA YPLFATGASD GQVHVFHGMV YDDYNKNALV VPVKILKHQR
     PVYAVAWHPT LAWLFTSTED GVVTAWTE