BOP1_LEIMA
ID BOP1_LEIMA Reviewed; 808 AA.
AC Q4QH39;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN ORFNames=LmjF11.0410, LmjF_11_0410;
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin;
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B.G., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; FR796407; CAJ02534.1; -; Genomic_DNA.
DR RefSeq; XP_001681509.1; XM_001681457.1.
DR AlphaFoldDB; Q4QH39; -.
DR SMR; Q4QH39; -.
DR STRING; 5664.LmjF.11.0410; -.
DR EnsemblProtists; CAJ02534; CAJ02534; LMJF_11_0410.
DR GeneID; 5649783; -.
DR KEGG; lma:LMJF_11_0410; -.
DR VEuPathDB; TriTrypDB:LmjF.11.0410; -.
DR VEuPathDB; TriTrypDB:LMJLV39_110009500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_110009600; -.
DR VEuPathDB; TriTrypDB:LMJSD75_110009700; -.
DR eggNOG; KOG0650; Eukaryota.
DR InParanoid; Q4QH39; -.
DR OMA; MRPAKGE; -.
DR Proteomes; UP000000542; Chromosome 11.
DR GO; GO:0005730; C:nucleolus; ISO:GeneDB.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..808
FT /note="Ribosome biogenesis protein BOP1 homolog"
FT /id="PRO_0000370412"
FT REPEAT 430..469
FT /note="WD 1"
FT REPEAT 640..680
FT /note="WD 2"
FT REPEAT 682..720
FT /note="WD 3"
FT REPEAT 724..766
FT /note="WD 4"
FT REPEAT 777..808
FT /note="WD 5"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 91191 MW; 727B69EDA7B06B36 CRC64;
MTSPKGKPSP KRSAPAPATA ALTPCAEERT EGATSSASAS ASSHISSSFD SPRDDTVVLT
GYTAESEHSA HGYERLHDII LQGSDTDADS EDGRANEDDV ILFPHAEELS NAAAGVGGDD
DNGRVVRLGT TQHLDESDSS EDEPTLNRVG DIPLEWYKDE DHIGYDIEGK KLMKKERSAL
ERLLEATDDP NAMRTIYDAL HDEKKTLSNA DLQLIFNLQR NRTTNPNYDM YSEVQEDTVV
FDPLNHPLAR SGGPSKKAFV PALHDMKVIA KMVRRLRKEE AERRLRPAKE EKEEEDQLLW
DDSHVEMDTH THFKYFNRIP KPKLPPPGTF ESYRPPPEYL PSERAKQRQA RLRTIDRKEH
FLPQSFDALR HVPFYHHTIQ DRYQRCLDLA FFPRAQRTRL VVDPDKLLPE LPDPKDLRPY
PEKLSFHYKG HTATVRSVSV SPNGQYLATG CDDHLVRVFE VQTGRLMKRY DMGAPVQQVE
FCPSTSLNIL AVAVEYSLVF IVPTFAAHTL VNDHTIRFLR APGLSAGQRE AAHALGAVDT
LGGRAVTQTA LDADETAHEA TADLHDIEER EKRAEFVDAS AKERNAGIVV KIAMHAKVKK
FCFHIKGDYL CALCPKDHVK YRQTIMLQLS KRKVFCPFRK FSEVVTDCRF HPREPIFFLA
TTNSVRCYNL MAHRLQRRFK ASGGVTTCLS IHPEGDNFLV GDTTSHTSWF DMDFSDKPYK
RMRSHKGVVN ALAFHPKTNA YPLFATGASD GQVHVFHGMV YDDYNKNALV VPVKILKHQR
PVYAVAWHPT LAWLFTSTED GVVTAWTE
