ID   BOP1_MONBE              Reviewed;         799 AA.
AC   A9UZS7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000255|HAMAP-Rule:MF_03027};
GN   ORFNames=37129;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CH991551; EDQ89285.1; -; Genomic_DNA.
DR   RefSeq; XP_001745861.1; XM_001745809.1.
DR   AlphaFoldDB; A9UZS7; -.
DR   SMR; A9UZS7; -.
DR   STRING; 81824.XP_001745861.1; -.
DR   EnsemblProtists; EDQ89285; EDQ89285; MONBRDRAFT_37129.
DR   GeneID; 5891182; -.
DR   KEGG; mbr:MONBRDRAFT_37129; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   InParanoid; A9UZS7; -.
DR   OMA; MRPAKGE; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..799
FT                   /note="Ribosome biogenesis protein BOP1 homolog"
FT                   /id="PRO_0000370409"
FT   REPEAT          457..498
FT                   /note="WD 1"
FT   REPEAT          500..538
FT                   /note="WD 2"
FT   REPEAT          584..626
FT                   /note="WD 3"
FT   REPEAT          629..669
FT                   /note="WD 4"
FT   REPEAT          670..709
FT                   /note="WD 5"
FT   REPEAT          713..752
FT                   /note="WD 6"
FT   REPEAT          769..799
FT                   /note="WD 7"
FT   REGION          1..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..124
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   799 AA;  90954 MW;  948F863E691DC070 CRC64;
     MPRRVRAQKR TAGVVEDEEV KAEQVRREHK AKQKQAVGSD AEQEEEELFP DSLHGPDSES
     DVTDDEQIDE EARQADRDLL KELVTLQGLN GEDPSDADND DDDDEEEAAS DDDDEEEDAE
     PSSDSSNEAS DAGQEEGTTD PHTTTDDKAS ATTQMVVYSS DDDTSDEEHS LNRVGRIPME
     WYEDYEHIGY DLNGKRIRKP KQKDRLEKFL DAFEAGNNGR TIYDPVTGKE IELTDDDINM
     IKRIQSGQLP DTGINPYEDY VDFFTHEKMQ TPVVDKPEPK RRFVPSKWEH KKIMKIVRSI
     RKGLIKLPTS DDEKDKSSEE EQYYDVWGNE DDPNDPRIKV RQANHIAAPK VALPHHAESY
     NPPEEYLPTD AEAEKWRNAH EDDRERNYLP HKYGSLRLVP AYDQYIQERF HRCLDLYLCP
     RARRIRMNVD PEDLLPKLPK PEDLQPFPSA PSLVYRGHKA RVTSISCDPT GQWLVSGSDD
     KTIRVWEIST GRCVRVVTVD AEVNMVAWCP NAGVSIVAVA HGHTVSLICP RVATAAIDKA
     TAVLCNQSIE KPSQGAEEGM RATPTWNRIR GERQDQDGIF FEIPHHAEVM QVTWHHKGNY
     FASVMPRAET QSVCVHSLNR QSTQHPFQKR NRDVQRVLFH PTQPLFFVAT KTHVRVYNLQ
     AQALVKKLLT GVRWLSSLAI HPAGDNLIIG SYDKRLCWFD MDLSIKPYKI LRYHKYALRQ
     VCFHKKYPIF ASCGDDGNVH VLHGMVYNDL GQNPLIVPVK IIKAHNQTSD GMGVMDCTFH
     PSQPWLFSAG SDGSIKLHV