BOP1_RAT
ID BOP1_RAT Reviewed; 731 AA.
AC Q562C2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ribosome biogenesis protein BOP1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Block of proliferation 1 protein {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=Bop1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111 AND SER-112, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. The complex is held together by BOP1, which interacts with PES1
CC via its N-terminal domain and with WDR12 via a high-affinity
CC interaction between the seven-bladed beta-propeller domains of the 2
CC proteins. The NOP7 complex associates with the 66S pre-ribosome. The
CC PeBoW complex associates with DDX27, BOP1 interacts directly with
CC DDX27. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; BC092594; AAH92594.1; -; mRNA.
DR RefSeq; NP_001019421.1; NM_001024250.1.
DR AlphaFoldDB; Q562C2; -.
DR SMR; Q562C2; -.
DR STRING; 10116.ENSRNOP00000025133; -.
DR iPTMnet; Q562C2; -.
DR PhosphoSitePlus; Q562C2; -.
DR jPOST; Q562C2; -.
DR PaxDb; Q562C2; -.
DR PRIDE; Q562C2; -.
DR Ensembl; ENSRNOT00000025134; ENSRNOP00000025133; ENSRNOG00000021773.
DR GeneID; 300050; -.
DR KEGG; rno:300050; -.
DR UCSC; RGD:1310589; rat.
DR CTD; 23246; -.
DR RGD; 1310589; Bop1.
DR eggNOG; KOG0650; Eukaryota.
DR GeneTree; ENSGT00390000018422; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q562C2; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR PhylomeDB; Q562C2; -.
DR TreeFam; TF300437; -.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q562C2; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000021773; Expressed in pancreas and 20 other tissues.
DR Genevisible; Q562C2; RN.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISO:RGD.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; ISO:RGD.
DR GO; GO:0008283; P:cell population proliferation; ISO:RGD.
DR GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISO:RGD.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; ISO:RGD.
DR GO; GO:0000027; P:ribosomal large subunit assembly; ISO:RGD.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISO:RGD.
DR GO; GO:0006364; P:rRNA processing; ISO:RGD.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis;
KW rRNA processing; WD repeat.
FT CHAIN 1..731
FT /note="Ribosome biogenesis protein BOP1"
FT /id="PRO_0000370386"
FT REPEAT 396..435
FT /note="WD 1"
FT REPEAT 437..477
FT /note="WD 2"
FT REPEAT 517..559
FT /note="WD 3"
FT REPEAT 562..600
FT /note="WD 4"
FT REPEAT 603..642
FT /note="WD 5"
FT REPEAT 646..685
FT /note="WD 6"
FT REPEAT 701..731
FT /note="WD 7"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..412
FT /note="Sufficient for nucleolar localization"
FT /evidence="ECO:0000250"
FT COMPBIAS 34..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 107
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q14137"
FT MOD_RES 111
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 112
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 731 AA; 82640 MW; 0CAAB45CF7A2FF63 CRC64;
MAGACGKHHM SPGSLPGKRR LEPDQEPQIQ EPLLLSDPDS SLSDSEESVF SGLEDSGSDT
SDEDTEEVAR AGCDKDNRTE KTSEEQEQAV PPCPRAEEAG ALTRDEYEED SSDEEDIRNT
VGNVPLAWYD DFPHVGYDLD GKRIYKPLRT RDELDQFLDK MDDPDFWRTV QDKMTGSDLR
LTDEQVALVH RLQRGQFGDS GFDPYEPAVD FFSGDIMIHP VTNRPADKRS FIPSLVEKEK
VSRLVHAIKM GWIKPRRPPD STPSFYDLWA QEDPNAVLGR HKMHVPAPKL ALPGHAESYN
PPPEYLPTEE ERLAWMQQEP IERKLNFLPQ KFPSLRTVPA YGRFIQERFE RCLDLYLCPR
QRKMRVNVDP EDLIPKLPRP RDLQPFPVCQ ALVYRGHSDL VRCLSVSPGG QWLASGSDDG
TLRLWEVATA RCMKTVRVGG VIRSIAWNPN PTICLVAAAM DDAVVLLNPA LGDRLLVGST
DQLLETFTPP EEPTLQPAHW LEVSEEERQR GLRLRICHSK PVTQVTWHGR GDYLAVVLSS
QGHTQVLIHQ LSRRRSQSPF RRSHGQVQCV AFHPTRPFLL VASQRSIRIY HLLRQELTKK
LMPNCKWVSS MAVHPAGDNI ICGSYDSKLV WFDLDLSTKP YKVLRHHKKA LRAVAFHPRY
PLFASGSDDG SVIVCHGMVY NDLLQNPLLV PVKVLKGHSL TRDLGVLDVA FHPTQPWVFS
SGADGTIRLF S
