ID   BOP1_XENTR              Reviewed;         729 AA.
AC   A4IHS2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Ribosome biogenesis protein bop1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Block of proliferation 1 protein {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=bop1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the PeBoW complex, which is required for
CC       maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and
CC       wdr12. The complex is held together by bop1, which interacts with pes1
CC       via its N-terminal domain and with wdr12 via a high-affinity
CC       interaction between the seven-bladed beta-propeller domains of the 2
CC       proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; BC135662; AAI35663.1; -; mRNA.
DR   RefSeq; NP_001096309.1; NM_001102839.1.
DR   AlphaFoldDB; A4IHS2; -.
DR   SMR; A4IHS2; -.
DR   DNASU; 100124887; -.
DR   GeneID; 100124887; -.
DR   KEGG; xtr:100124887; -.
DR   CTD; 23246; -.
DR   Xenbase; XB-GENE-6454222; bop1.
DR   InParanoid; A4IHS2; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..729
FT                   /note="Ribosome biogenesis protein bop1"
FT                   /id="PRO_0000370390"
FT   REPEAT          394..433
FT                   /note="WD 1"
FT   REPEAT          435..475
FT                   /note="WD 2"
FT   REPEAT          515..557
FT                   /note="WD 3"
FT   REPEAT          560..598
FT                   /note="WD 4"
FT   REPEAT          601..640
FT                   /note="WD 5"
FT   REPEAT          644..683
FT                   /note="WD 6"
FT   REPEAT          699..729
FT                   /note="WD 7"
FT   REGION          1..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  83015 MW;  DF25D502A263158E CRC64;
     MKKGSKREAG GPQAEQPEPL FSGEDRSLSD GNIVDESDSE ESQYSGLEDS GSDSTEDEEE
     HSSEEIQQNP GKSPKEIRKV PHRPSKSEAN SAAAEEDKPS AAKEYENDSS DEEDIRNTVG
     NIPMEWYQDF PHIGYDLDGR KIFKPLRSKD QLEQFLDKME NPDYWRTVHD KKTGQDVRLT
     DEQVDLVERL QRGQFGDINY DPYQPSIDFF THETMIHPVT NRPADKRSFI PSLIEKEKVS
     KLVHAIKMGW IQPRKPRDDS PAYYDLWAKE DPNAILGRHK MHVPAPKLPL PGHEQSYNPP
     PEYLMSEEER LAWEQQDPED RKVPFLPQRF PCLRAVPGYA RFIHERFERC LDLYLCPRQR
     KMRVNVDPED LIPKLPKPRD LQPFPTVQSL IYRGHKDLVR CISVAPSGQW LVSGSDDCTV
     RFWEVGTGRC MKSVLLEGAV KSISWNPNPG LVLVAACVEH SVVLINPGLG DRLLCGATDQ
     HIGGYQPPEE EGQQPVSWGE AEGTEYSNGL RLCIKHQKAV KQVTWHARGD YFAVVLPDNG
     NSQVLIHQLS RRRSQNPFRK NKGQVQKVLF HPTRPFFFVA TQRCVRVYNL LKQELSKKLL
     TNCKWVSSIA VHPAGDNLIC GSYDSKLAWF DMDLSTKPYK VLRHHKKALR AVSYHKQYPL
     FASGSDDGSV IVCHGMVYND LLQNPLIVPV KVLRGHAIHR DLGVLDVIFH PTQPWVFSSG
     ADATIRLYT