BOP3_YEAST
ID BOP3_YEAST Reviewed; 396 AA.
AC P53958; D6W1D7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein BOP3;
DE AltName: Full=Bypass of PAM1 protein 3;
GN Name=BOP3; OrderedLocusNames=YNL042W; ORFNames=N2670;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-345.
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8740423;
RX DOI=10.1002/(sici)1097-0061(199604)12:5<493::aid-yea929>3.0.co;2-w;
RA Nasr F., Becam A.-M., Herbert C.J.;
RT "The sequence of 12.8 kb from the left arm of chromosome XIV reveals a
RT sigma element, a pro-tRNA and six complete open reading frames, one of
RT which encodes a protein similar to the human leukotriene A4 hydrolase.";
RL Yeast 12:493-499(1996).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP FUNCTION.
RX PubMed=15796894; DOI=10.1016/j.bbrc.2005.02.169;
RA Hwang G.-W., Furuoya Y., Hiroshima A., Furuchi T., Naganuma A.;
RT "Overexpression of Bop3 confers resistance to methylmercury in
RT Saccharomyces cerevisiae through interaction with other proteins such as
RT Fkh1, Rts1, and Msn2.";
RL Biochem. Biophys. Res. Commun. 330:378-385(2005).
CC -!- FUNCTION: Involved in resistance to methylmercury. Overexpression
CC suppresses a PAM1-SLV3 double null mutation.
CC {ECO:0000269|PubMed:15796894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
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DR EMBL; Z71318; CAA95909.1; -; Genomic_DNA.
DR EMBL; X94547; CAA64240.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10503.1; -; Genomic_DNA.
DR PIR; S62964; S62964.
DR RefSeq; NP_014356.1; NM_001182881.1.
DR AlphaFoldDB; P53958; -.
DR BioGRID; 35782; 34.
DR DIP; DIP-4192N; -.
DR IntAct; P53958; 4.
DR MINT; P53958; -.
DR STRING; 4932.YNL042W; -.
DR iPTMnet; P53958; -.
DR PaxDb; P53958; -.
DR PRIDE; P53958; -.
DR EnsemblFungi; YNL042W_mRNA; YNL042W; YNL042W.
DR GeneID; 855686; -.
DR KEGG; sce:YNL042W; -.
DR SGD; S000004987; BOP3.
DR VEuPathDB; FungiDB:YNL042W; -.
DR eggNOG; ENOG502S5HG; Eukaryota.
DR HOGENOM; CLU_058506_0_0_1; -.
DR InParanoid; P53958; -.
DR OMA; QQYYKLE; -.
DR BioCyc; YEAST:G3O-33078-MON; -.
DR PRO; PR:P53958; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P53958; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR InterPro; IPR021216; DUF2722.
DR Pfam; PF10846; DUF2722; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..396
FT /note="Protein BOP3"
FT /id="PRO_0000203456"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 43749 MW; 1751D22644393D95 CRC64;
MSTFNSYSQP KESNDNSHNN VNKSKSLLDI IFGTNVSEWA FSENALMKAM DLKIEQEKTK
QQYYKLENLN RSIELFKLAS SSGLPINQIH KLFNTDHGVP ASSPMKAGGN QPHNNTEGTQ
SSENLPRLNG SMKSLKPLNM NTVSPTPMSR QPSPYKFPAS SSTGGISHST VTNVQRRANS
PARIGASAVA ALNDNISIKE EDVARRIPSG TKSQESPLNK KPTSLHSRNL SLPIGKFTNP
NIPSTMTSIL SFNRDQQQPL SQPLPPPPQQ QQDLHTHNLH TIPRKPGMVQ KKHRRARSTS
SFGVIDLSII DEAKEKQVQR SPSPIHSNVS VALTSHDKPI ESNMKEQPNM LQSVREGRQV
HDDLDDRTCS ESSSRNESPV RTITKDNSVG KILNST
