BOPA_BURM7
ID BOPA_BURM7 Reviewed; 512 AA.
AC A3MCH8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Effector protein BopA;
GN Name=bopA; OrderedLocusNames=BMA10247_A0764;
OS Burkholderia mallei (strain NCTC 10247).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=320389;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 10247;
RX PubMed=20333227; DOI=10.1093/gbe/evq003;
RA Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA Nierman W.C.;
RT "Continuing evolution of Burkholderia mallei through genome reduction and
RT large-scale rearrangements.";
RL Genome Biol. Evol. 2:102-116(2010).
CC -!- FUNCTION: Plays a role in mediating bacterial evasion from the host
CC autophagic pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the bsa
CC type III secretion system. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BopA/IcsB family. {ECO:0000305}.
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DR EMBL; CP000547; ABO02033.1; -; Genomic_DNA.
DR RefSeq; WP_004187505.1; NZ_CP007801.1.
DR AlphaFoldDB; A3MCH8; -.
DR GeneID; 56597868; -.
DR KEGG; bmaz:BM44_4984; -.
DR KEGG; bmn:BMA10247_A0764; -.
DR PATRIC; fig|320389.8.peg.5719; -.
DR OMA; MSKFICQ; -.
DR Proteomes; UP000002284; Chromosome II.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR Gene3D; 4.10.1330.10; -; 1.
DR InterPro; IPR011070; Globular_prot_asu/bsu.
DR InterPro; IPR015203; SptP_N.
DR InterPro; IPR044899; SptP_N_sf.
DR Pfam; PF09119; SicP-binding; 1.
DR SUPFAM; SSF56568; SSF56568; 1.
PE 3: Inferred from homology;
KW Coiled coil; Secreted; Virulence.
FT CHAIN 1..512
FT /note="Effector protein BopA"
FT /id="PRO_0000344021"
FT COILED 347..377
FT /evidence="ECO:0000255"
SQ SEQUENCE 512 AA; 56800 MW; FAF23B924EEC15C5 CRC64;
MINVGAFVAS ARSGARVVVG GDARGPVVSA ARLGMKERLF AFLAHVPLLK HCDAVRRYAE
QVRMENRRSL EVFVLALSKR YGPEGAKAAF DYGARRDGAP LDQRRVRNMV SIAEHFHGTG
DAKPLARQMV FRSWECRGLD HPGHASLTIK NQADADAGRH VYEHVSWWPN QRLGSKEHFD
RIEPKTLDGY RIDKRSEISS ATEQRLREGD AARRKILADG FKYANQDERH DALFFPRAGQ
KLDKDAEWGL SARKVYFPAI GFNHDRRDTD RPRAFVLFGL NEAAMLRDAR TVKEGAKSGE
LKYRMISKKE NCASMALRVL RAGGAEHFVP YTAAWISEDP NHAHAYALAV QARIDALNQR
RADVERRCER LRDSASVRQA WRAFSEAGGA SASPLAEDAG RGRASAHMRQ ARLDEHAREV
ERIGAYFAEL SAGRSGKHRD RADADLADAM KRCAPSARDD VAALTRKASV LVETLGRHLD
APPPSDSSAL RRLAAHAMIG RIEAFMAAAI AA