ID   BOPA_BURM9              Reviewed;         512 AA.
AC   A2S1Q9; A2S1Q8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Effector protein BopA;
GN   Name=bopA; OrderedLocusNames=BMA10229_2081;
OS   Burkholderia mallei (strain NCTC 10229).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=412022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 10229;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Plays a role in mediating bacterial evasion from the host
CC       autophagic pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the bsa
CC       type III secretion system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BopA/IcsB family. {ECO:0000305}.
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DR   EMBL; CP000545; ABN00177.2; -; Genomic_DNA.
DR   RefSeq; WP_004187505.1; NC_008835.1.
DR   AlphaFoldDB; A2S1Q9; -.
DR   EnsemblBacteria; ABN00177; ABN00177; BMA10229_2081.
DR   GeneID; 56597868; -.
DR   KEGG; bml:BMA10229_2081; -.
DR   HOGENOM; CLU_531773_0_0_4; -.
DR   OMA; MSKFICQ; -.
DR   Proteomes; UP000002283; Chromosome II.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   Gene3D; 4.10.1330.10; -; 1.
DR   InterPro; IPR011070; Globular_prot_asu/bsu.
DR   InterPro; IPR015203; SptP_N.
DR   InterPro; IPR044899; SptP_N_sf.
DR   Pfam; PF09119; SicP-binding; 1.
DR   SUPFAM; SSF56568; SSF56568; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..512
FT                   /note="Effector protein BopA"
FT                   /id="PRO_0000344020"
FT   COILED          347..377
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   512 AA;  56800 MW;  FAF23B924EEC15C5 CRC64;
     MINVGAFVAS ARSGARVVVG GDARGPVVSA ARLGMKERLF AFLAHVPLLK HCDAVRRYAE
     QVRMENRRSL EVFVLALSKR YGPEGAKAAF DYGARRDGAP LDQRRVRNMV SIAEHFHGTG
     DAKPLARQMV FRSWECRGLD HPGHASLTIK NQADADAGRH VYEHVSWWPN QRLGSKEHFD
     RIEPKTLDGY RIDKRSEISS ATEQRLREGD AARRKILADG FKYANQDERH DALFFPRAGQ
     KLDKDAEWGL SARKVYFPAI GFNHDRRDTD RPRAFVLFGL NEAAMLRDAR TVKEGAKSGE
     LKYRMISKKE NCASMALRVL RAGGAEHFVP YTAAWISEDP NHAHAYALAV QARIDALNQR
     RADVERRCER LRDSASVRQA WRAFSEAGGA SASPLAEDAG RGRASAHMRQ ARLDEHAREV
     ERIGAYFAEL SAGRSGKHRD RADADLADAM KRCAPSARDD VAALTRKASV LVETLGRHLD
     APPPSDSSAL RRLAAHAMIG RIEAFMAAAI AA