ID   BOPA_BURP1              Reviewed;         512 AA.
AC   Q3JL32;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Effector protein BopA;
GN   Name=bopA; OrderedLocusNames=BURPS1710b_A0562;
OS   Burkholderia pseudomallei (strain 1710b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320372;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1710b;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Plays a role in mediating bacterial evasion from the host
CC       autophagic pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the bsa
CC       type III secretion system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BopA/IcsB family. {ECO:0000305}.
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DR   EMBL; CP000125; ABA51593.1; -; Genomic_DNA.
DR   RefSeq; WP_004528810.1; NC_007435.1.
DR   AlphaFoldDB; Q3JL32; -.
DR   EnsemblBacteria; ABA51593; ABA51593; BURPS1710b_A0562.
DR   KEGG; bpm:BURPS1710b_A0562; -.
DR   HOGENOM; CLU_531773_0_0_4; -.
DR   OMA; MSKFICQ; -.
DR   OrthoDB; 384699at2; -.
DR   Proteomes; UP000002700; Chromosome II.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   Gene3D; 4.10.1330.10; -; 1.
DR   InterPro; IPR011070; Globular_prot_asu/bsu.
DR   InterPro; IPR015203; SptP_N.
DR   InterPro; IPR044899; SptP_N_sf.
DR   Pfam; PF09119; SicP-binding; 1.
DR   SUPFAM; SSF56568; SSF56568; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..512
FT                   /note="Effector protein BopA"
FT                   /id="PRO_0000344024"
FT   COILED          347..377
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   512 AA;  56832 MW;  CB47108F4B11D8FC CRC64;
     MINVDAFVAS ARSGARVVVG GDARGPVVSA ARLGMKERLF AFLAHVPLLK HCDAVRRYAE
     QVRMENRRSL EVFVLALSKR YGPEGAKAAF DYGARRDGAP LDQRRVRNMV SIAEHFHGTG
     DAKPLARQMV FRSWECRGLD HPGHASLTIK NQADADAGRH VYEHVSWWPN QRLGSKEHFD
     RIEPKTLDGY RIDKRSEISS ATEQRLREGD AARRKILADG FKYANQDERH DARFFPRAGQ
     KLDKDAEWGL SARKVYFPAI GFNHDRRDTD RPRAFVLFGL NEAAMLRDAR TVKEGAKSGE
     LMYQMISKKE NCASMALRVL RAGGAEHFVP YTAAWISEDP NHAHAYALAV QARIDALNQR
     RADVERRCER LRDSASVRQA WRAFSEAGGA SASPLAEDAG RGRASAHMRQ ARLDEHAREV
     ERIGAYFAEL SAGRSGKHRD RADAALADAM KRCAPSARDD VAALTRKASV LVETLGRHLD
     APPPSDSSAL RRLAAHAMIG RIEAFMAAAI AA