ID   BOPA_BURP6              Reviewed;         512 AA.
AC   A3NLC6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Effector protein BopA;
GN   Name=bopA; OrderedLocusNames=BURPS668_A2153;
OS   Burkholderia pseudomallei (strain 668).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=668;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: Plays a role in mediating bacterial evasion from the host
CC       autophagic pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the bsa
CC       type III secretion system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BopA/IcsB family. {ECO:0000305}.
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DR   EMBL; CP000571; ABN88245.1; -; Genomic_DNA.
DR   RefSeq; WP_011853452.1; NC_009075.1.
DR   AlphaFoldDB; A3NLC6; -.
DR   EnsemblBacteria; ABN88245; ABN88245; BURPS668_A2153.
DR   KEGG; bpd:BURPS668_A2153; -.
DR   HOGENOM; CLU_531773_0_0_4; -.
DR   OMA; MSKFICQ; -.
DR   Proteomes; UP000002153; Chromosome II.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   Gene3D; 4.10.1330.10; -; 1.
DR   InterPro; IPR011070; Globular_prot_asu/bsu.
DR   InterPro; IPR015203; SptP_N.
DR   InterPro; IPR044899; SptP_N_sf.
DR   Pfam; PF09119; SicP-binding; 1.
DR   SUPFAM; SSF56568; SSF56568; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Secreted; Virulence.
FT   CHAIN           1..512
FT                   /note="Effector protein BopA"
FT                   /id="PRO_0000344025"
FT   COILED          347..376
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   512 AA;  56781 MW;  FAF22B4822C46937 CRC64;
     MINVGAFVAS ARSGARVVVG GDARGPVVSA ARLGMKERLF AFLAHVPLLK HCDAVRRYAE
     QVRMENRRSL EVFVLALSKR YGPEGAKAAF DYGARRDGAP LDQRRVRNMV SIAEHFHGTG
     DAKPLARQMV FRSWECRGLD HPGHASLTIK NQADADAGRH VYEHVSWWPN QRLGSKEHFD
     RIEPKTLDGY RIDKRSEISS ATEQRLREGD AARRKILADG FKYANQDERH DALFFPRAGQ
     KLDKDAEWGL SARKVYFPAI GFNHDRRDTD RPRAFVLFGL NEAAMLRDAR TVKEGAKSGE
     LKYRMISKKE NCASMALRVL RAGGAEHFVP YTAAWISEDP NHAHAYALAV QARIDALNQR
     RADVERRCER LHDSASVRQA WRAFSEAGGA SASPLAEDAG RGRASAHMRQ ARLDEHAREV
     ERIGAYFAEL SAGRSGKHRD RADADLADAM KRCAPSARDD VAALTRKASV LVETLGRHLD
     APPPSDSSAL RRLAAHAMIG RIEAFMAAAI AA