ID   BOPA_BURPS              Reviewed;         512 AA.
AC   Q63K42;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Effector protein BopA;
GN   Name=bopA; OrderedLocusNames=BPSS1524;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
RN   [2]
RP   ROLE IN VIRULENCE, AND SUBCELLULAR LOCATION.
RC   STRAIN=576;
RX   PubMed=15289563; DOI=10.1099/mic.0.27146-0;
RA   Stevens M.P., Haque A., Atkins T., Hill J., Wood M.W., Easton A.,
RA   Nelson M., Underwood-Fowler C., Titball R.W., Bancroft G.J., Galyov E.E.;
RT   "Attenuated virulence and protective efficacy of a Burkholderia
RT   pseudomallei bsa type III secretion mutant in murine models of
RT   melioidosis.";
RL   Microbiology 150:2669-2676(2004).
RN   [3]
RP   ROLE IN EVADING HOST AUTOPHAGIC PATHWAY.
RX   PubMed=18483470; DOI=10.4161/auto.6246;
RA   Cullinane M., Gong L., Li X., Lazar-Adler N., Tra T., Wolvetang E.,
RA   Prescott M., Boyce J.D., Devenish R.J., Adler B.;
RT   "Stimulation of autophagy suppresses the intracellular survival of
RT   Burkholderia pseudomallei in mammalian cell lines.";
RL   Autophagy 4:744-753(2008).
CC   -!- FUNCTION: Plays a role in mediating bacterial evasion from the host
CC       autophagic pathway. {ECO:0000269|PubMed:15289563,
CC       ECO:0000269|PubMed:18483470}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15289563}.
CC       Note=Secreted via the bsa type III secretion system.
CC   -!- SIMILARITY: Belongs to the BopA/IcsB family. {ECO:0000305}.
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DR   EMBL; BX571966; CAH38997.1; -; Genomic_DNA.
DR   RefSeq; WP_004528810.1; NZ_CP009537.1.
DR   RefSeq; YP_111530.1; NC_006351.1.
DR   AlphaFoldDB; Q63K42; -.
DR   STRING; 272560.BPSS1524; -.
DR   PRIDE; Q63K42; -.
DR   EnsemblBacteria; CAH38997; CAH38997; BPSS1524.
DR   KEGG; bps:BPSS1524; -.
DR   PATRIC; fig|272560.51.peg.4878; -.
DR   eggNOG; ENOG5032XT2; Bacteria.
DR   OMA; MSKFICQ; -.
DR   Proteomes; UP000000605; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   Gene3D; 4.10.1330.10; -; 1.
DR   InterPro; IPR011070; Globular_prot_asu/bsu.
DR   InterPro; IPR015203; SptP_N.
DR   InterPro; IPR044899; SptP_N_sf.
DR   Pfam; PF09119; SicP-binding; 1.
DR   SUPFAM; SSF56568; SSF56568; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..512
FT                   /note="Effector protein BopA"
FT                   /id="PRO_0000344022"
FT   COILED          347..377
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   512 AA;  56832 MW;  CB47108F4B11D8FC CRC64;
     MINVDAFVAS ARSGARVVVG GDARGPVVSA ARLGMKERLF AFLAHVPLLK HCDAVRRYAE
     QVRMENRRSL EVFVLALSKR YGPEGAKAAF DYGARRDGAP LDQRRVRNMV SIAEHFHGTG
     DAKPLARQMV FRSWECRGLD HPGHASLTIK NQADADAGRH VYEHVSWWPN QRLGSKEHFD
     RIEPKTLDGY RIDKRSEISS ATEQRLREGD AARRKILADG FKYANQDERH DARFFPRAGQ
     KLDKDAEWGL SARKVYFPAI GFNHDRRDTD RPRAFVLFGL NEAAMLRDAR TVKEGAKSGE
     LMYQMISKKE NCASMALRVL RAGGAEHFVP YTAAWISEDP NHAHAYALAV QARIDALNQR
     RADVERRCER LRDSASVRQA WRAFSEAGGA SASPLAEDAG RGRASAHMRQ ARLDEHAREV
     ERIGAYFAEL SAGRSGKHRD RADAALADAM KRCAPSARDD VAALTRKASV LVETLGRHLD
     APPPSDSSAL RRLAAHAMIG RIEAFMAAAI AA