SYUB_BOVIN
ID SYUB_BOVIN Reviewed; 134 AA.
AC P33567;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Beta-synuclein;
DE AltName: Full=14 kDa brain-specific protein;
DE AltName: Full=Phosphoneuroprotein 14;
DE Short=PNP 14;
GN Name=SNCB;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Brain;
RX PubMed=8223629; DOI=10.1111/j.1432-1033.1993.tb18337.x;
RA Nakajo S., Tsukada K., Omata K., Nakamura Y., Nakaya K.;
RT "A new brain-specific 14-kDa protein is a phosphoprotein. Its complete
RT amino acid sequence and evidence for phosphorylation.";
RL Eur. J. Biochem. 217:1057-1063(1993).
RN [2]
RP PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Brain;
RX PubMed=2230807; DOI=10.1111/j.1471-4159.1990.tb05792.x;
RA Nakajo S., Omata K., Aiuchi T., Shibayama T., Okahashi I., Ochiai H.,
RA Nakai Y., Nakaya K., Nakamura Y.;
RT "Purification and characterization of a novel brain-specific 14-kDa
RT protein.";
RL J. Neurochem. 55:2031-2038(1990).
CC -!- FUNCTION: May be involved in neuronal plasticity.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Specifically present in synapses around neurons but
CC not in glial cells.
CC -!- PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor
CC kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and
CC CaM-kinase II (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synuclein family. {ECO:0000305}.
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DR PIR; A60218; A60218.
DR PIR; S39046; S39046.
DR AlphaFoldDB; P33567; -.
DR BMRB; P33567; -.
DR STRING; 9913.ENSBTAP00000012928; -.
DR PaxDb; P33567; -.
DR eggNOG; ENOG502S0N5; Eukaryota.
DR InParanoid; P33567; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:1903136; F:cuprous ion binding; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1901214; P:regulation of neuron death; IBA:GO_Central.
DR GO; GO:0050808; P:synapse organization; IBA:GO_Central.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR InterPro; IPR001058; Synuclein.
DR InterPro; IPR002461; Synuclein_beta.
DR PANTHER; PTHR13820; PTHR13820; 1.
DR PANTHER; PTHR13820:SF4; PTHR13820:SF4; 1.
DR Pfam; PF01387; Synuclein; 1.
DR PRINTS; PR01213; BSYNUCLEIN.
DR PRINTS; PR01211; SYNUCLEIN.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..134
FT /note="Beta-synuclein"
FT /id="PRO_0000184034"
FT REPEAT 20..30
FT /note="1"
FT REPEAT 31..41
FT /note="2"
FT REPEAT 42..56
FT /note="3; approximate"
FT REPEAT 57..67
FT /note="4"
FT REGION 20..67
FT /note="4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-
FT X(4)"
FT REGION 97..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..134
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 118
FT /note="Phosphoserine; by BARK1, CK2 and GRK5"
FT /evidence="ECO:0000250|UniProtKB:Q16143"
SQ SEQUENCE 134 AA; 14277 MW; 484FA01A01979966 CRC64;
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTKEGVVQ GVASVAEKTK
EQASHLGGAV FSGAGNIAAA TGLVKKEEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE
EQPQEEYQEY EPEA