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SYUG_MACFA
ID   SYUG_MACFA              Reviewed;         127 AA.
AC   Q2PFW6;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Gamma-synuclein;
GN   Name=SNCG; ORFNames=QflA-20719;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RA   Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S.,
RA   Hashimoto K.;
RT   "Analysis of gene expression in cynomolgus monkey tissues by macaque cDNA
RT   oligo-chips.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in neurofilament network integrity. May be
CC       involved in modulating axonal architecture during development and in
CC       the adult. In vitro, increases the susceptibility of neurofilament-H to
CC       calcium-dependent proteases (By similarity). May also function in
CC       modulating the keratin network in skin. Activates the MAPK and Elk-1
CC       signal transduction pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: May be a centrosome-associated protein. Interacts with MYOC;
CC       affects its secretion and its aggregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
CC       cytoskeleton, spindle. Note=Associated with centrosomes in several
CC       interphase cells. In mitotic cells, localized to the poles of the
CC       spindle (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on
CC       residues distinct from the residue phosphorylated by other kinases (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synuclein family. {ECO:0000305}.
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DR   EMBL; AB220471; BAE73004.1; -; mRNA.
DR   RefSeq; NP_001270799.1; NM_001283870.1.
DR   RefSeq; XP_015311380.1; XM_015455894.1.
DR   AlphaFoldDB; Q2PFW6; -.
DR   STRING; 9541.XP_005565297.1; -.
DR   GeneID; 102121834; -.
DR   CTD; 6623; -.
DR   VEuPathDB; HostDB:ENSMFAG00000034096; -.
DR   eggNOG; ENOG502S3WF; Eukaryota.
DR   OMA; VPKAADQ; -.
DR   OrthoDB; 1544450at2759; -.
DR   Proteomes; UP000233100; Chromosome 9.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001058; Synuclein.
DR   InterPro; IPR002462; Synuclein_gamma.
DR   PANTHER; PTHR13820; PTHR13820; 1.
DR   Pfam; PF01387; Synuclein; 1.
DR   PRINTS; PR01214; GSYNUCLEIN.
DR   PRINTS; PR01211; SYNUCLEIN.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..127
FT                   /note="Gamma-synuclein"
FT                   /id="PRO_0000252356"
FT   REPEAT          20..30
FT                   /note="1"
FT   REPEAT          31..41
FT                   /note="2"
FT   REPEAT          42..56
FT                   /note="3; approximate"
FT   REPEAT          57..67
FT                   /note="4"
FT   REGION          20..67
FT                   /note="4 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-
FT                   V-X(4)"
FT   REGION          97..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         67
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q63544"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q63544"
FT   MOD_RES         124
FT                   /note="Phosphoserine; by BARK1, CaMK2 and CK2"
FT                   /evidence="ECO:0000250|UniProtKB:O76070"
SQ   SEQUENCE   127 AA;  13296 MW;  B93395CD3BDFDE12 CRC64;
     MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GTKTKENVVH SVTSVAEKTK
     EQANAVSEAV VSSVNTVAAK TVEEAENIAV TSGVVRKEDL KPSAPQQEGE AAKEKEEVAE
     EAQSGGD
 
 
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