SYUG_MACFA
ID SYUG_MACFA Reviewed; 127 AA.
AC Q2PFW6;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Gamma-synuclein;
GN Name=SNCG; ORFNames=QflA-20719;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Frontal cortex;
RA Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S.,
RA Hashimoto K.;
RT "Analysis of gene expression in cynomolgus monkey tissues by macaque cDNA
RT oligo-chips.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in neurofilament network integrity. May be
CC involved in modulating axonal architecture during development and in
CC the adult. In vitro, increases the susceptibility of neurofilament-H to
CC calcium-dependent proteases (By similarity). May also function in
CC modulating the keratin network in skin. Activates the MAPK and Elk-1
CC signal transduction pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: May be a centrosome-associated protein. Interacts with MYOC;
CC affects its secretion and its aggregation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
CC cytoskeleton, spindle. Note=Associated with centrosomes in several
CC interphase cells. In mitotic cells, localized to the poles of the
CC spindle (By similarity). {ECO:0000250}.
CC -!- PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on
CC residues distinct from the residue phosphorylated by other kinases (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synuclein family. {ECO:0000305}.
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DR EMBL; AB220471; BAE73004.1; -; mRNA.
DR RefSeq; NP_001270799.1; NM_001283870.1.
DR RefSeq; XP_015311380.1; XM_015455894.1.
DR AlphaFoldDB; Q2PFW6; -.
DR STRING; 9541.XP_005565297.1; -.
DR GeneID; 102121834; -.
DR CTD; 6623; -.
DR VEuPathDB; HostDB:ENSMFAG00000034096; -.
DR eggNOG; ENOG502S3WF; Eukaryota.
DR OMA; VPKAADQ; -.
DR OrthoDB; 1544450at2759; -.
DR Proteomes; UP000233100; Chromosome 9.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR InterPro; IPR001058; Synuclein.
DR InterPro; IPR002462; Synuclein_gamma.
DR PANTHER; PTHR13820; PTHR13820; 1.
DR Pfam; PF01387; Synuclein; 1.
DR PRINTS; PR01214; GSYNUCLEIN.
DR PRINTS; PR01211; SYNUCLEIN.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..127
FT /note="Gamma-synuclein"
FT /id="PRO_0000252356"
FT REPEAT 20..30
FT /note="1"
FT REPEAT 31..41
FT /note="2"
FT REPEAT 42..56
FT /note="3; approximate"
FT REPEAT 57..67
FT /note="4"
FT REGION 20..67
FT /note="4 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-
FT V-X(4)"
FT REGION 97..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63544"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63544"
FT MOD_RES 124
FT /note="Phosphoserine; by BARK1, CaMK2 and CK2"
FT /evidence="ECO:0000250|UniProtKB:O76070"
SQ SEQUENCE 127 AA; 13296 MW; B93395CD3BDFDE12 CRC64;
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GTKTKENVVH SVTSVAEKTK
EQANAVSEAV VSSVNTVAAK TVEEAENIAV TSGVVRKEDL KPSAPQQEGE AAKEKEEVAE
EAQSGGD