ID   SYU_TETCF               Reviewed;         143 AA.
AC   P37379;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Synuclein;
OS   Tetronarce californica (Pacific electric ray) (Torpedo californica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Tetronarce.
OX   NCBI_TaxID=7787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3411354; DOI=10.1523/jneurosci.08-08-02804.1988;
RA   Maroteaux L., Campanelli J.T., Scheller R.H.;
RT   "Synuclein: a neuron-specific protein localized to the nucleus and
RT   presynaptic nerve terminal.";
RL   J. Neurosci. 8:2804-2815(1988).
CC   -!- FUNCTION: May have a role in synaptic regulation or signal
CC       transduction.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Nervous system tissue. Found in the electric lobe,
CC       the brain and the spinal cord.
CC   -!- MISCELLANEOUS: Three isoforms are detected: 17.5 kDa, 18.5 kDa and 20.0
CC       kDa. In the neuronal cell soma, the 17.5 kDa species is predominant.
CC   -!- SIMILARITY: Belongs to the synuclein family. {ECO:0000305}.
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DR   PIR; A60887; A60887.
DR   AlphaFoldDB; P37379; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001058; Synuclein.
DR   InterPro; IPR002462; Synuclein_gamma.
DR   PANTHER; PTHR13820; PTHR13820; 2.
DR   Pfam; PF01387; Synuclein; 2.
DR   PRINTS; PR01214; GSYNUCLEIN.
DR   PRINTS; PR01211; SYNUCLEIN.
PE   2: Evidence at transcript level;
KW   Nucleus; Repeat.
FT   CHAIN           1..143
FT                   /note="Synuclein"
FT                   /id="PRO_0000184041"
FT   REPEAT          20..30
FT                   /note="1"
FT   REPEAT          31..41
FT                   /note="2"
FT   REPEAT          42..52
FT                   /note="3"
FT   REPEAT          53..67
FT                   /note="4; approximate"
FT   REPEAT          68..78
FT                   /note="5"
FT   REGION          20..78
FT                   /note="5 X 11 AA tandem repeats of [EGST]-K-T-K-[EQ]-[GQ]-
FT                   [VA]-X(4)"
FT   REGION          113..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   143 AA;  14831 MW;  51872507471C2BC2 CRC64;
     MDVLKKGFSF AKEGVVAAAE KTKQGVQDAA EKTKQGVQDA AEKTKEGVMY VGTKTKEGVV
     QSVNTVTEKT KEQANVVGGA VVAGVNTVAS KTVEGVENVA AASGVVKLDE HGREIPAEQV
     AEGKQTTQEP LVEATEATEE TGK