ID   BOPE_BURTA              Reviewed;         261 AA.
AC   Q2T704;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Guanine nucleotide exchange factor BopE;
DE   AltName: Full=Effector protein BopE;
GN   Name=bopE; OrderedLocusNames=BTH_II0848;
OS   Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 /
OS   E264).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700388 / DSM 13276 / CIP 106301 / E264;
RX   PubMed=16336651; DOI=10.1186/1471-2164-6-174;
RA   Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C.,
RA   DeShazer D.;
RT   "Bacterial genome adaptation to niches: divergence of the potential
RT   virulence genes in three Burkholderia species of different survival
RT   strategies.";
RL   BMC Genomics 6:174-174(2005).
CC   -!- FUNCTION: Activator for both CDC42 and RAC1 by directly interacting
CC       with these Rho GTPases and acting as a guanine nucleotide exchange
CC       factor (GEF). This activation results in actin cytoskeleton
CC       rearrangements and stimulates membrane ruffling, thus promoting
CC       bacterial entry into non-phagocytic cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with human CDC42 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the bsa
CC       type III secretion system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC       {ECO:0000305}.
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DR   EMBL; CP000085; ABC36199.1; -; Genomic_DNA.
DR   RefSeq; WP_009896161.1; NZ_CP008786.1.
DR   AlphaFoldDB; Q2T704; -.
DR   SMR; Q2T704; -.
DR   PRIDE; Q2T704; -.
DR   EnsemblBacteria; ABC36199; ABC36199; BTH_II0848.
DR   KEGG; bte:BTH_II0848; -.
DR   HOGENOM; CLU_1064256_0_0_4; -.
DR   OMA; RQAIRHF; -.
DR   OrthoDB; 934519at2; -.
DR   Proteomes; UP000001930; Chromosome II.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
DR   GO; GO:0090630; P:activation of GTPase activity; IEA:InterPro.
DR   Gene3D; 1.10.4120.10; -; 1.
DR   InterPro; IPR005414; SopE.
DR   InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR   InterPro; IPR016019; SopE_GEF_dom.
DR   Pfam; PF07487; SopE_GEF; 1.
DR   PIRSF; PIRSF034781; SecIII_sopE; 1.
DR   PRINTS; PR01593; SOPEPROTEIN.
DR   SUPFAM; SSF81832; SSF81832; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Guanine-nucleotide releasing factor; Secreted;
KW   Virulence.
FT   CHAIN           1..261
FT                   /note="Guanine nucleotide exchange factor BopE"
FT                   /id="PRO_0000344034"
FT   REGION          241..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  28593 MW;  D44364C1EF3E5D5B CRC64;
     MTYNPRIGGF THVKQASFDV HVKRSEARPR TSFAQQIKRI FSKIGETLGQ LFRHRAPDGA
     PGRVKLQGVR YVGSYRPTGD ARQAIRHFVD EAVKQVAHAR TPEIRQDAEF GRQVYEATLC
     AIFSEAKDRF CMDPATRAGN VRPAFIAALG DAARATGLPG ADKQGVFTPS GAGTNPLYTE
     IRLRADTLMG AELAARPEYR ELQSYARQQA IDLVANALPG ERSNTLAEFR QTVQTLEATY
     RRAAQDASRD EKGAANAADG A