ID   BOP_PONAB               Reviewed;         364 AA.
AC   Q5R6M8;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Protein Bop {ECO:0000250|UniProtKB:Q7L3V2};
DE   AltName: Full=BH3-only protein;
GN   Name=RTL10 {ECO:0000250|UniProtKB:Q7L3V2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could induce apoptosis in a BH3 domain-dependent manner. The
CC       direct interaction network of Bcl-2 family members may play a key role
CC       in modulation of RTL10/BOP activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via BH3 domain) with VDAC1. Interacts with pro-
CC       survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1,
CC       BCL2A1 and BCL2L2. Interacts with BAX and BAK1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- DOMAIN: The BH3 motif is required for pro-apoptotic activity and for
CC       interaction with pro-survival Bcl-2 family members. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR860459; CAH92582.1; -; mRNA.
DR   AlphaFoldDB; Q5R6M8; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0097345; P:mitochondrial outer membrane permeabilization; ISS:UniProtKB.
DR   GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR   InterPro; IPR031298; Bop.
DR   InterPro; IPR032549; DUF4939.
DR   InterPro; IPR032567; LDOC1-rel.
DR   PANTHER; PTHR15503; PTHR15503; 1.
DR   PANTHER; PTHR15503:SF4; PTHR15503:SF4; 1.
DR   Pfam; PF16297; DUF4939; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Mitochondrion; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Protein Bop"
FT                   /id="PRO_0000295911"
FT   REGION          67..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  39061 MW;  379374B7DD3EE204 CRC64;
     MPRGQCRQQG PRIPIWAAAN YANAHPWQQM DQTSPGVAYT PLVDPWIERP CCGDTLCART
     TMEQKSTASG ACGGKPAERG PLTGRMPSSR PHRVDFCWVP GSDPGTFDGS PWLLDRFLAQ
     LGDYMSFHFE HYQDNISRVC EILGRLTGQA RAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ
     DLNSFAEYHA VVPCPLPLAS SQLPVASQLP VVKQYLARFL KGLALDMGTA PRSLPAAMAT
     PAAFGSNSIS RSALLEQQLT KESTPGPKEP PVLPSSACSS KPGPVEPASS QPEEAAPTPV
     PGLLESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE APEGPGEPPL
     SLGF