BOR4_ARATH
ID BOR4_ARATH Reviewed; 683 AA.
AC Q9XI23;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Boron transporter 4;
GN Name=BOR4; OrderedLocusNames=At1g15460; ORFNames=F9L1.41;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18048682; DOI=10.1126/science.1146634;
RA Miwa K., Takano J., Omori H., Seki M., Shinozaki K., Fujiwara T.;
RT "Plants tolerant of high boron levels.";
RL Science 318:1417-1417(2007).
CC -!- FUNCTION: Efflux-type boron transporter polarly localized in roots.
CC Boron is essential for maintaining the integrity of plants cell walls.
CC {ECO:0000269|PubMed:18048682}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18048682}; Multi-
CC pass membrane protein {ECO:0000269|PubMed:18048682}.
CC -!- TISSUE SPECIFICITY: Expressed in the distal sides of epidermal cells in
CC the elongation zone of roots. {ECO:0000269|PubMed:18048682}.
CC -!- INDUCTION: Up-regulated by boron supply. {ECO:0000269|PubMed:18048682}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31.3) family.
CC {ECO:0000305}.
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DR EMBL; AC007591; AAD39673.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29326.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60142.1; -; Genomic_DNA.
DR EMBL; AY069887; AAL47440.1; -; mRNA.
DR RefSeq; NP_001319010.1; NM_001332166.1.
DR RefSeq; NP_172999.1; NM_101415.4.
DR AlphaFoldDB; Q9XI23; -.
DR SMR; Q9XI23; -.
DR STRING; 3702.AT1G15460.1; -.
DR iPTMnet; Q9XI23; -.
DR PaxDb; Q9XI23; -.
DR PRIDE; Q9XI23; -.
DR ProteomicsDB; 240630; -.
DR EnsemblPlants; AT1G15460.1; AT1G15460.1; AT1G15460.
DR EnsemblPlants; AT1G15460.2; AT1G15460.2; AT1G15460.
DR GeneID; 838116; -.
DR Gramene; AT1G15460.1; AT1G15460.1; AT1G15460.
DR Gramene; AT1G15460.2; AT1G15460.2; AT1G15460.
DR KEGG; ath:AT1G15460; -.
DR Araport; AT1G15460; -.
DR TAIR; locus:2037808; AT1G15460.
DR eggNOG; KOG1172; Eukaryota.
DR HOGENOM; CLU_002289_3_2_1; -.
DR InParanoid; Q9XI23; -.
DR OMA; HDWLEGF; -.
DR OrthoDB; 265068at2759; -.
DR PhylomeDB; Q9XI23; -.
DR PRO; PR:Q9XI23; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XI23; baseline and differential.
DR Genevisible; Q9XI23; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0080139; F:borate efflux transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046713; P:borate transport; IMP:TAIR.
DR GO; GO:0080029; P:cellular response to boron-containing substance levels; IDA:UniProtKB.
DR GO; GO:0050801; P:ion homeostasis; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR PANTHER; PTHR11453; PTHR11453; 1.
DR Pfam; PF00955; HCO3_cotransp; 3.
PE 2: Evidence at transcript level;
KW Anion exchange; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..683
FT /note="Boron transporter 4"
FT /id="PRO_0000079240"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..477
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 499..565
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 587..683
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 617..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 76700 MW; 863956AC609BC1C5 CRC64;
MEEERVDSSK RLFRGIVADL RGRALCYKED WVAGLRSGFG ILAPTTYIFF ASALPVIAFG
EQLSRDTEGA LSTVETLAST ALCGVIHSIL GGQPLLILGV AEPTVLMYVY LYNFAIGRPE
LGKQLYLAWA AWVCVWTALL LFVMAILNTA DIINRFTRVA GELFGMLISV LFIQQAIKGM
VSEFGMPKDE DSKLEKYKFE WLYTNGLLGL IFTFGLLYTA LKSRKARSWR YGTGWYRSFI
ADYGVPLMVV VWTALSFSTP SKLPSGVPRR LFSPLPWDSP SLSHWTVIKD MGKVSPGYIF
AAFIPALMIA GLYFFDHSVA SQLAQQKEFN LKKPSAYHYD ILLLGFMTLI CGLLGLPPSN
GVLPQSPMHT KSLAVLKRQL IRRKMVKTAK ESIRKRETSS QVYENMQEVF IEMDKSPLAQ
TDPSVIIELQ DLKEAVMKSN DEEREGDEES GFDPEKHLDA YLPVRVNEQR VSNLLQSLLV
AGAVLAMPAI KLIPTSILWG YFAYMAIDSL PGNQFFERLT LLFVPTSRRF KVLEGAHASF
VEKVPYKSMA AFTLLQIFYF GLCYGVTWIP VAGIMFPVPF FLLIAIRQYI LPKLFNPAHL
RELDAAEYEE IPGTPRNPLE LSFRSNDSKR GVQEGDAEIL DELTTSRGEL KVRTLNLNED
KGNQIYPKEK VKAGDGDMST TRE
