ID   BORA_DANRE              Reviewed;         551 AA.
AC   Q5U3U6;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein aurora borealis;
GN   Name=bora; ORFNames=zgc:101616;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the activation of aurka at the onset of mitosis.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BORA family. {ECO:0000305}.
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DR   EMBL; BC085389; AAH85389.1; -; mRNA.
DR   RefSeq; NP_001007451.1; NM_001007450.1.
DR   AlphaFoldDB; Q5U3U6; -.
DR   STRING; 7955.ENSDARP00000062627; -.
DR   PaxDb; Q5U3U6; -.
DR   GeneID; 555606; -.
DR   KEGG; dre:555606; -.
DR   CTD; 79866; -.
DR   ZFIN; ZDB-GENE-041114-165; bora.
DR   eggNOG; ENOG502S85H; Eukaryota.
DR   InParanoid; Q5U3U6; -.
DR   OrthoDB; 539473at2759; -.
DR   PhylomeDB; Q5U3U6; -.
DR   Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   PRO; PR:Q5U3U6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007088; P:regulation of mitotic nuclear division; ISS:UniProtKB.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
DR   InterPro; IPR023252; Aurora_borealis_protein.
DR   PANTHER; PTHR14728; PTHR14728; 1.
DR   Pfam; PF15280; BORA_N; 1.
DR   PRINTS; PR02038; AURORABORA.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Reference proteome.
FT   CHAIN           1..551
FT                   /note="Protein aurora borealis"
FT                   /id="PRO_0000273208"
FT   REGION          194..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..431
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..453
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..540
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  60335 MW;  6B4F5DF67024D3E6 CRC64;
     MGDIAKIHIT PETPARPTIL NPFESPNDYH RLHESVVPSP SVFKSCKSSS ATPAKFKWSI
     DEMANLLPVE IDPEDIHRQA VFFSQARADS EIEEKRQHAI EQFFTKGAIV PSPWGPLTSK
     QSMKLPHHKS PLSPLVTEEI QPPKKINAIC QTVLSLPVDF NLEKVLGDYY KTEELTEQVQ
     ESLSSSSLRR KLFLDGHDSG SESSTPSSPD RNSPSVHPSS RELMSSAIVS PLQCGIPTGT
     PMSGQFSSSP IQGQCRAYSL GSVTSPMFSE RSSPAFKSPI LSPIRLQQSV TPESGERKRL
     SFLSPNCVPK GSSDINMNRS GESPLVEGCS PIRSCSPFQS RPRNRACMWA SPAHISPILH
     PVLHDKENIH ITQHLPTMDL DATSTDPHAQ QDSLHAESSE SEASVAVSEQ MEQDELFVKD
     TGENVETNGK ECESDNEDEG ENELGEEESC AWVPEEDTAS PVRLSSTGTG SVPNAESTHM
     FLSLLAEGSI TPYDTSMQVD SGYNTHSVCT TSLMDTLSSD SQSKEMLDTH TSEESGPFTR
     HTKPKLFVPP H