ID   BORA_DROPS              Reviewed;         544 AA.
AC   Q2LYY4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein aurora borealis;
GN   Name=bora; ORFNames=GA19938;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for the activation of Aurora-A (aur) at the onset of
CC       mitosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with aur. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Shuttles between the cytoplasm and the nucleus. In interphase
CC       cells, it is nuclear. Upon entry into mitosis, it is excluded from the
CC       nucleus and translocates into the cytoplasm in a Cdc2-dependent manner
CC       (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated by aur. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BORA family. {ECO:0000305}.
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DR   EMBL; CH379069; EAL29725.2; -; Genomic_DNA.
DR   RefSeq; XP_001353989.2; XM_001353953.3.
DR   AlphaFoldDB; Q2LYY4; -.
DR   STRING; 7237.FBpp0275481; -.
DR   EnsemblMetazoa; FBtr0277043; FBpp0275481; FBgn0079934.
DR   GeneID; 4813628; -.
DR   KEGG; dpo:Dpse_GA19938; -.
DR   eggNOG; ENOG502S85H; Eukaryota.
DR   HOGENOM; CLU_464825_0_0_1; -.
DR   InParanoid; Q2LYY4; -.
DR   OMA; TQFEWNI; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0079934; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0045167; P:asymmetric protein localization involved in cell fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR023252; Aurora_borealis_protein.
DR   PANTHER; PTHR14728; PTHR14728; 1.
DR   Pfam; PF15280; BORA_N; 1.
DR   PRINTS; PR02038; AURORABORA.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..544
FT                   /note="Protein aurora borealis"
FT                   /id="PRO_0000273211"
FT   REGION          28..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..391
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..446
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  59727 MW;  E0DBBFF4B105079F CRC64;
     MYTDEVRTPQ ALKSRYFTNL GDLNCRTRRN SATGNSSVAS AATPTNGGKQ NTKCSPQMST
     LVCTPPPKRF HKIRNPFEGA LADRLHLPLI ASPSLFRART PQLSSTQFEW NIDEVSQLTP
     ADVEPHETQF HDSPDPELES KAQMAISAFF KESLIVPSPV DCPLRKNRII LNADHTPISN
     KSSSGRRGRD CSVQTELTLP PILPKALEEA LRPYLQPHLA GGTSGRFKSR SSGSDVFNSS
     MRRKLFDLHN VIVLGEKEAV QSPQMVGSSP QGKQTMFAGR LSDSASGEGS FGSLSPIRNL
     CGLPLGTPDD GNRSSKRKLL LINELEFPSP IAPPEHLSRR LVHSKVEASI SSNEQHDTLS
     ELTGTGRPAC RFTPDRSSSP MQALEHSDSS INQRVSRLRV NSTRQLPSQS FLETVDQALF
     EEVEADDTDE PEADQESDED EEEAEAMQLS TISFNCSSSN SDTPRGHRRH RSANRKNLSQ
     SFSANLEEVE AQRVKTAPPV INPPAQRIGL YRVDSGFNET SIISTFACSQ DISMACCSTP
     STRP