ID   BORC5_BOVIN             Reviewed;         196 AA.
AC   Q08DP2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=BLOC-1-related complex subunit 5 {ECO:0000305};
GN   Name=BORCS5 {ECO:0000250|UniProtKB:Q969J3};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       Thereby, it may indirectly play a role in cell spreading and motility.
CC       {ECO:0000250|UniProtKB:Q969J3}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. Interacts with ARL8B, KIF5A, KLC1 and PLEKHM2; links the
CC       lysosomal BORC complex to the microtubule plus-end-directed kinesin
CC       motor. {ECO:0000250|UniProtKB:Q969J3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q969J3};
CC       Lipid-anchor {ECO:0000250|UniProtKB:Q969J3}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q969J3}.
CC   -!- PTM: Myristoylation at Gly-2 mediates attachment to lysosome membranes.
CC       {ECO:0000250|UniProtKB:Q969J3}.
CC   -!- SIMILARITY: Belongs to the BORCS5 family. {ECO:0000305}.
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DR   EMBL; BC123638; AAI23639.1; -; mRNA.
DR   RefSeq; NP_001069823.1; NM_001076355.1.
DR   AlphaFoldDB; Q08DP2; -.
DR   SMR; Q08DP2; -.
DR   STRING; 9913.ENSBTAP00000011832; -.
DR   PaxDb; Q08DP2; -.
DR   PRIDE; Q08DP2; -.
DR   Ensembl; ENSBTAT00000011832; ENSBTAP00000011832; ENSBTAG00000008989.
DR   GeneID; 614947; -.
DR   KEGG; bta:614947; -.
DR   CTD; 118426; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008989; -.
DR   VGNC; VGNC:26542; BORCS5.
DR   eggNOG; KOG4515; Eukaryota.
DR   GeneTree; ENSGT00390000015016; -.
DR   HOGENOM; CLU_064176_1_0_1; -.
DR   InParanoid; Q08DP2; -.
DR   OMA; RFSEIPR; -.
DR   OrthoDB; 1446665at2759; -.
DR   TreeFam; TF316379; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000008989; Expressed in oocyte and 105 other tissues.
DR   ExpressionAtlas; Q08DP2; baseline.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0031224; C:intrinsic component of membrane; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0072384; P:organelle transport along microtubule; ISS:UniProtKB.
DR   GO; GO:1903744; P:positive regulation of anterograde synaptic vesicle transport; IBA:GO_Central.
DR   InterPro; IPR018780; TBORCS5.
DR   PANTHER; PTHR31634; PTHR31634; 1.
DR   Pfam; PF10158; LOH1CR12; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Lysosome; Membrane; Myristate; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q969J3"
FT   CHAIN           2..196
FT                   /note="BLOC-1-related complex subunit 5"
FT                   /id="PRO_0000318595"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         71
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D920"
FT   MOD_RES         75
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q969J3"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q969J3"
SQ   SEQUENCE   196 AA;  22200 MW;  D55BAC08706F8EB8 CRC64;
     MGSEQSSEAE SRPNDLNSSV TPSPAKHRAK MDDIVVVAQG SQASRNVSND PDVIKLQEIP
     TFQPLLKGLL SGQTSPTNAK LEKLDSQQVL QLCLRYQDHL HQCAEAVAFD QNALVKRIKE
     MDLSVETLFS FMQERQKRYA KYAEQIQKVN EMSAILRRIQ MGIDQTVPLL ERLNSLLPEA
     ERLEPFSVKP DRELRL