BORC5_CHICK
ID BORC5_CHICK Reviewed; 185 AA.
AC Q5ZJA9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=BLOC-1-related complex subunit 5 {ECO:0000305};
GN Name=BORCS5 {ECO:0000250|UniProtKB:Q969J3};
GN ORFNames=RCJMB04_19j2 {ECO:0000312|EMBL:CAG32184.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: As part of a BORC-like complex may play a role in lysosomes
CC movement and localization at the cell periphery. Associated with the
CC cytosolic face of lysosomes, this complex may couple lysosomes to
CC microtubule plus-end-directed kinesin motor.
CC {ECO:0000250|UniProtKB:Q969J3}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q969J3};
CC Lipid-anchor {ECO:0000250|UniProtKB:Q969J3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q969J3}.
CC -!- SIMILARITY: Belongs to the BORCS5 family. {ECO:0000305}.
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DR EMBL; AJ720525; CAG32184.1; -; mRNA.
DR RefSeq; NP_001026528.1; NM_001031357.1.
DR AlphaFoldDB; Q5ZJA9; -.
DR SMR; Q5ZJA9; -.
DR STRING; 9031.ENSGALP00000021904; -.
DR Ensembl; ENSGALT00000068215; ENSGALP00000056705; ENSGALG00000040393.
DR GeneID; 426116; -.
DR KEGG; gga:426116; -.
DR CTD; 118426; -.
DR VEuPathDB; HostDB:geneid_426116; -.
DR eggNOG; KOG4515; Eukaryota.
DR GeneTree; ENSGT00390000015016; -.
DR InParanoid; Q5ZJA9; -.
DR PhylomeDB; Q5ZJA9; -.
DR PRO; PR:Q5ZJA9; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000040393; Expressed in cerebellum and 12 other tissues.
DR ExpressionAtlas; Q5ZJA9; baseline and differential.
DR GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0031224; C:intrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0072384; P:organelle transport along microtubule; ISS:UniProtKB.
DR GO; GO:1903744; P:positive regulation of anterograde synaptic vesicle transport; IBA:GO_Central.
DR InterPro; IPR018780; TBORCS5.
DR PANTHER; PTHR31634; PTHR31634; 1.
DR Pfam; PF10158; LOH1CR12; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..185
FT /note="BLOC-1-related complex subunit 5"
FT /id="PRO_0000318598"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 20934 MW; 8A0A238FF6813290 CRC64;
MAGVNGSHAS PSPAKQRAKM DDIVVVAPGT QSSRNVSNDP DVIKLQEIPT FQPLLKGLLS
GQTSPTNTKL EKLDPHQVLQ LCLRYQDHLH QCAEAVAFDQ NALVKRIKEM DLSVETLYSF
MQERQKKYAK YAEQIQKVNE MSAILRRIQM GIDQTVPLME RLNSMLPESE QLEPFSMKPD
REIKS