BORC5_XENTR
ID BORC5_XENTR Reviewed; 196 AA.
AC A8E5U3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=BLOC-1-related complex subunit 5 {ECO:0000305};
GN Name=borcs5 {ECO:0000250|UniProtKB:Q969J3};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of a BORC-like complex may play a role in lysosomes
CC movement and localization at the cell periphery. Associated with the
CC cytosolic face of lysosomes, this complex may couple lysosomes to
CC microtubule plus-end-directed kinesin motor.
CC {ECO:0000250|UniProtKB:Q969J3}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q969J3};
CC Lipid-anchor {ECO:0000250|UniProtKB:Q969J3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q969J3}.
CC -!- SIMILARITY: Belongs to the BORCS5 family. {ECO:0000305}.
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DR EMBL; BC153719; AAI53720.1; -; mRNA.
DR RefSeq; NP_001106433.1; NM_001112962.1.
DR RefSeq; XP_012813950.1; XM_012958496.2.
DR AlphaFoldDB; A8E5U3; -.
DR SMR; A8E5U3; -.
DR STRING; 8364.ENSXETP00000022104; -.
DR PaxDb; A8E5U3; -.
DR DNASU; 100127605; -.
DR GeneID; 100127605; -.
DR KEGG; xtr:100127605; -.
DR CTD; 118426; -.
DR Xenbase; XB-GENE-940511; borcs5.
DR eggNOG; KOG4515; Eukaryota.
DR HOGENOM; CLU_064176_1_0_1; -.
DR InParanoid; A8E5U3; -.
DR OrthoDB; 1446665at2759; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR ExpressionAtlas; A8E5U3; baseline.
DR GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0031224; C:intrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0072384; P:organelle transport along microtubule; ISS:UniProtKB.
DR GO; GO:1903744; P:positive regulation of anterograde synaptic vesicle transport; IBA:GO_Central.
DR InterPro; IPR018780; TBORCS5.
DR PANTHER; PTHR31634; PTHR31634; 1.
DR Pfam; PF10158; LOH1CR12; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..196
FT /note="BLOC-1-related complex subunit 5"
FT /id="PRO_0000318601"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 22096 MW; BCF9D9560CE9BF19 CRC64;
MGAEQSSEGD LRQNDLSSSV SPSPAKQKAK MDDIVVVAPG TQSLRNVSKD PEVIKLQEIP
TFQPLLKGLL SGQTSPTNVR LERLDSPQVL QLCVRYQEHL HQCAEAVSFD QNALVKRIKE
MDSSVDGLYS LMQERQKRFA KYAEQIQKVN EMSAILRRIQ MGIDQTVPLM EKLNIMLPEG
ERLEPFCMSP DRESKP