ID   BORC6_BOVIN             Reviewed;         353 AA.
AC   Q3SX20;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=BLOC-1-related complex subunit 6 {ECO:0000305};
GN   Name=BORCS6 {ECO:0000250|UniProtKB:Q96GS4};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       {ECO:0000250|UniProtKB:Q96GS4}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. {ECO:0000250|UniProtKB:Q96GS4}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96GS4}.
CC   -!- SIMILARITY: Belongs to the BORCS6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI04552.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC104551; AAI04552.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001035655.2; NM_001040565.1.
DR   AlphaFoldDB; Q3SX20; -.
DR   STRING; 9913.ENSBTAP00000002241; -.
DR   PaxDb; Q3SX20; -.
DR   PRIDE; Q3SX20; -.
DR   GeneID; 539395; -.
DR   KEGG; bta:539395; -.
DR   CTD; 54785; -.
DR   eggNOG; KOG4514; Eukaryota.
DR   HOGENOM; CLU_081385_1_0_1; -.
DR   InParanoid; Q3SX20; -.
DR   OrthoDB; 1229804at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   InterPro; IPR019314; BORCS6.
DR   PANTHER; PTHR13440; PTHR13440; 1.
DR   Pfam; PF10157; BORCS6; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..353
FT                   /note="BLOC-1-related complex subunit 6"
FT                   /id="PRO_0000286826"
FT   REGION          23..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..252
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D6W8"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS4"
FT   MOD_RES         194
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS4"
FT   MOD_RES         197
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS4"
SQ   SEQUENCE   353 AA;  37171 MW;  F15996E5816E180E CRC64;
     MESPRGRPGP ETDLLALGEQ QAAIFGDGPG QTPSERPSDL RLSEDEEAEN VGGASCHPKA
     SLKTSSCSFV HPPEWEAPED KPGRGGTFSG AGSRLGAPDP EFDLHGSSRR KDPEPPEAKP
     ESERVCRRGS PVGGGMDVEQ KEDDNEAAEA GRGGRSFSSR LQDSRSLDGL SGACGGPASS
     GGAESGAGGG RRATISSPLE LEGTVSRHGD LTHFVANNLQ LKIRLSGAPQ PPPPAPTRPC
     SAPTPTPAIP PIDPDVLRDL ERLSRELGGR VDRLLRGLGG AVQELTALSV GCIQTYRDAV
     DSLGEAVDMS IKGMYTLLAR CEELERALQP VQGLARQVRD IRRTLEVLEA LCK