ID   BORC6_RAT               Reviewed;         360 AA.
AC   Q66H43;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=BLOC-1-related complex subunit 6 {ECO:0000305};
GN   Name=Borcs6 {ECO:0000312|RGD:1563885};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       {ECO:0000250|UniProtKB:Q96GS4}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. {ECO:0000250|UniProtKB:Q96GS4}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96GS4}.
CC   -!- SIMILARITY: Belongs to the BORCS6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC082026; AAH82026.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001017474.2; NM_001017474.1.
DR   AlphaFoldDB; Q66H43; -.
DR   STRING; 10116.ENSRNOP00000008507; -.
DR   iPTMnet; Q66H43; -.
DR   PhosphoSitePlus; Q66H43; -.
DR   jPOST; Q66H43; -.
DR   PaxDb; Q66H43; -.
DR   PRIDE; Q66H43; -.
DR   Ensembl; ENSRNOT00000008507; ENSRNOP00000008507; ENSRNOG00000006513.
DR   GeneID; 497934; -.
DR   KEGG; rno:497934; -.
DR   UCSC; RGD:1563885; rat.
DR   CTD; 54785; -.
DR   RGD; 1563885; Borcs6.
DR   eggNOG; KOG4514; Eukaryota.
DR   GeneTree; ENSGT00490000043453; -.
DR   HOGENOM; CLU_782948_0_0_1; -.
DR   InParanoid; Q66H43; -.
DR   OMA; RHKDPAP; -.
DR   OrthoDB; 1229804at2759; -.
DR   PhylomeDB; Q66H43; -.
DR   PRO; PR:Q66H43; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000006513; Expressed in testis and 19 other tissues.
DR   Genevisible; Q66H43; RN.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   InterPro; IPR019314; BORCS6.
DR   PANTHER; PTHR13440; PTHR13440; 1.
DR   Pfam; PF10157; BORCS6; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..360
FT                   /note="BLOC-1-related complex subunit 6"
FT                   /id="PRO_0000286828"
FT   REGION          1..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..155
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D6W8"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D6W8"
FT   MOD_RES         173
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS4"
FT   MOD_RES         201
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS4"
FT   MOD_RES         204
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS4"
SQ   SEQUENCE   360 AA;  37828 MW;  CEF146096D4AE6A4 CRC64;
     MEAARGRLGP EQDLSTGADH QAVTFSGRPS RTLSKPPSAR TLSGEEEAES VGVASRHPRP
     SPKTSSGSIA HRPELDTWED KPSARATPSG ARGSRGTSGS EHTPPPSSWY PEPEPSEDQP
     SALTVCRRGS PGGVEMNVEL PQQEGDDDDD GDDEEAADRA GHSFPSRLQD SRSLDGLSGA
     CGGGGSSSSG EAGAGGGRRA TISSPLELEG TVSRHGDLTH FVANNLQLKI RLSGAPSPVP
     PASGRPCLTP APTPTIPPID PDVLRDLERL SRELGGRVDR LLCGLGGAVQ ELTALSVGCI
     QTYRDAVDSL GEAVDMSIKG MYTLLARCEE LERALQPVQG LARQVRDIRR TLEVLEALCK