BORC7_DANRE
ID BORC7_DANRE Reviewed; 103 AA.
AC Q4V8S9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=BLOC-1-related complex subunit 7 {ECO:0000305};
GN Name=borcs7 {ECO:0000250|UniProtKB:Q96B45};
GN ORFNames=si:ch211-67n3.3 {ECO:0000312|EMBL:CAM12925.1},
GN zgc:114169 {ECO:0000312|EMBL:AAH97219.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of a BORC-like complex may play a role in lysosomes
CC movement and localization at the cell periphery. Associated with the
CC cytosolic face of lysosomes, this complex may couple lysosomes to
CC microtubule plus-end-directed kinesin motor.
CC {ECO:0000250|UniProtKB:Q96B45}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96B45}.
CC -!- SIMILARITY: Belongs to the BORCS7 family. {ECO:0000305}.
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DR EMBL; AL928951; CAM12925.1; -; Genomic_DNA.
DR EMBL; BC097219; AAH97219.1; -; mRNA.
DR RefSeq; NP_001035077.1; NM_001039988.1.
DR AlphaFoldDB; Q4V8S9; -.
DR SMR; Q4V8S9; -.
DR STRING; 7955.ENSDARP00000071850; -.
DR PaxDb; Q4V8S9; -.
DR Ensembl; ENSDART00000077383; ENSDARP00000071850; ENSDARG00000055070.
DR GeneID; 664759; -.
DR KEGG; dre:664759; -.
DR CTD; 119032; -.
DR ZFIN; ZDB-GENE-050913-112; borcs7.
DR eggNOG; ENOG502S2QS; Eukaryota.
DR GeneTree; ENSGT00390000015849; -.
DR HOGENOM; CLU_150749_1_0_1; -.
DR InParanoid; Q4V8S9; -.
DR OMA; FIESKMR; -.
DR OrthoDB; 1626208at2759; -.
DR PhylomeDB; Q4V8S9; -.
DR TreeFam; TF314767; -.
DR PRO; PR:Q4V8S9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000055070; Expressed in early embryo and 28 other tissues.
DR GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR032143; BORCS7.
DR PANTHER; PTHR31397; PTHR31397; 1.
DR Pfam; PF16088; BORCS7; 1.
PE 3: Inferred from homology;
KW Lysosome; Membrane; Reference proteome.
FT CHAIN 1..103
FT /note="BLOC-1-related complex subunit 7"
FT /id="PRO_0000359787"
SQ SEQUENCE 103 AA; 11590 MW; 4C74C08CDBB0E3BA CRC64;
MASSETQPRF GQSVKGLLSD KVTSCSGDVI ALTRQVLKGS RSQELLSQAA RNMVIQEDAI
LHSEDSLRKM SIITTHLQYQ QEAIQKNVEH SKNLQDQLRH LMK