ID   BORC7_MOUSE             Reviewed;         105 AA.
AC   Q9CRC6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=BLOC-1-related complex subunit 7 {ECO:0000305};
GN   Name=Borcs7 {ECO:0000312|MGI:MGI:1913689};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Adrenal gland, Pancreas, and Small intestine;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       {ECO:0000250|UniProtKB:Q96B45}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. {ECO:0000250|UniProtKB:Q96B45}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96B45}.
CC   -!- SIMILARITY: Belongs to the BORCS7 family. {ECO:0000305}.
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DR   EMBL; AK007626; BAB25145.1; -; mRNA.
DR   EMBL; AK008215; BAB25539.1; -; mRNA.
DR   EMBL; AK046524; BAC32771.1; -; mRNA.
DR   EMBL; BC027506; AAH27506.1; -; mRNA.
DR   CCDS; CCDS38011.1; -.
DR   RefSeq; NP_079839.1; NM_025563.3.
DR   AlphaFoldDB; Q9CRC6; -.
DR   SMR; Q9CRC6; -.
DR   ComplexPortal; CPX-5061; BORC complex.
DR   STRING; 10090.ENSMUSP00000074447; -.
DR   iPTMnet; Q9CRC6; -.
DR   PhosphoSitePlus; Q9CRC6; -.
DR   EPD; Q9CRC6; -.
DR   MaxQB; Q9CRC6; -.
DR   PaxDb; Q9CRC6; -.
DR   PeptideAtlas; Q9CRC6; -.
DR   PRIDE; Q9CRC6; -.
DR   ProteomicsDB; 273697; -.
DR   DNASU; 66439; -.
DR   Ensembl; ENSMUST00000074912; ENSMUSP00000074447; ENSMUSG00000062376.
DR   GeneID; 66439; -.
DR   KEGG; mmu:66439; -.
DR   UCSC; uc008hub.1; mouse.
DR   CTD; 119032; -.
DR   MGI; MGI:1913689; Borcs7.
DR   VEuPathDB; HostDB:ENSMUSG00000062376; -.
DR   eggNOG; ENOG502S2QS; Eukaryota.
DR   GeneTree; ENSGT00390000015849; -.
DR   HOGENOM; CLU_150749_1_0_1; -.
DR   InParanoid; Q9CRC6; -.
DR   OMA; FIESKMR; -.
DR   OrthoDB; 1626208at2759; -.
DR   PhylomeDB; Q9CRC6; -.
DR   TreeFam; TF314767; -.
DR   BioGRID-ORCS; 66439; 3 hits in 40 CRISPR screens.
DR   ChiTaRS; Borcs7; mouse.
DR   PRO; PR:Q9CRC6; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q9CRC6; protein.
DR   Bgee; ENSMUSG00000062376; Expressed in facial nucleus and 248 other tissues.
DR   Genevisible; Q9CRC6; MM.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; IC:ComplexPortal.
DR   GO; GO:0032418; P:lysosome localization; IC:ComplexPortal.
DR   GO; GO:0072384; P:organelle transport along microtubule; IC:ComplexPortal.
DR   GO; GO:0051036; P:regulation of endosome size; IC:ComplexPortal.
DR   GO; GO:0062196; P:regulation of lysosome size; IC:ComplexPortal.
DR   InterPro; IPR032143; BORCS7.
DR   PANTHER; PTHR31397; PTHR31397; 1.
DR   Pfam; PF16088; BORCS7; 1.
PE   1: Evidence at protein level;
KW   Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..105
FT                   /note="BLOC-1-related complex subunit 7"
FT                   /id="PRO_0000089788"
SQ   SEQUENCE   105 AA;  11546 MW;  01FC0894BAF10CEB CRC64;
     MATGTPDSQA RFGQSVKGLL TEKVNTCGTD VIALTKQVLK GSRSSELLGQ AARNMVLQED
     AILHSEDSLR KMAIITTHLQ YQQEAIQKNV EQSPDLQDQL SHLLK