ID   BORC8_DANRE             Reviewed;         124 AA.
AC   A3KQI3; B3DG62;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=BLOC-1-related complex subunit 8 {ECO:0000305};
GN   Name=borcs8 {ECO:0000250|UniProtKB:Q96FH0};
GN   ORFNames=si:ch211-125m10.2 {ECO:0000312|EMBL:AAI62286.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of a BORC-like complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, this complex may couple lysosomes to
CC       microtubule plus-end-directed kinesin motor.
CC       {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SIMILARITY: Belongs to the BORCS8 family. {ECO:0000305}.
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DR   EMBL; BX649643; CAM56297.1; -; Genomic_DNA.
DR   EMBL; BC162286; AAI62286.1; -; mRNA.
DR   EMBL; BC162309; AAI62309.1; -; mRNA.
DR   RefSeq; NP_001091717.1; NM_001098247.2.
DR   AlphaFoldDB; A3KQI3; -.
DR   STRING; 7955.ENSDARP00000096205; -.
DR   PaxDb; A3KQI3; -.
DR   PeptideAtlas; A3KQI3; -.
DR   Ensembl; ENSDART00000105432; ENSDARP00000096205; ENSDARG00000071339.
DR   GeneID; 558180; -.
DR   KEGG; dre:558180; -.
DR   CTD; 729991; -.
DR   ZFIN; ZDB-GENE-050208-757; borcs8.
DR   eggNOG; KOG4523; Eukaryota.
DR   GeneTree; ENSGT00390000014856; -.
DR   HOGENOM; CLU_151479_0_0_1; -.
DR   InParanoid; A3KQI3; -.
DR   OMA; CYDVEYA; -.
DR   OrthoDB; 1473909at2759; -.
DR   PhylomeDB; A3KQI3; -.
DR   TreeFam; TF313931; -.
DR   PRO; PR:A3KQI3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000071339; Expressed in tail and 29 other tissues.
DR   ExpressionAtlas; A3KQI3; baseline.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019320; BORCS8.
DR   PANTHER; PTHR21146; PTHR21146; 1.
DR   Pfam; PF10167; BORCS8; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..124
FT                   /note="BLOC-1-related complex subunit 8"
FT                   /id="PRO_0000286446"
FT   REGION          102..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   124 AA;  14095 MW;  9ACC0CCB12C33B87 CRC64;
     MEDQEMQLKV KRVTDKFTES MYVLANEPSI ALYRLQEHVR RSLPELVQHK TDMQSWEEQS
     QGAIYTVEYA CSAVKSMTNS SLYFKNIDGL LRQAISLKEQ ISSSQGRSAV INPNETPAHT
     SVTP