ID   BORC8_DICDI             Reviewed;         240 AA.
AC   Q54JC6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=BLOC-1-related complex subunit 8 homolog {ECO:0000305};
GN   ORFNames=DDB_G0288149 {ECO:0000312|dictyBase:DDB_G0288149};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May participate in the coupling of lysosomes to microtubule
CC       plus-end-directed kinesin motor. {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SIMILARITY: Belongs to the BORCS8 family. {ECO:0000305}.
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DR   EMBL; AAFI02000109; EAL63362.1; -; Genomic_DNA.
DR   RefSeq; XP_636867.1; XM_631775.1.
DR   AlphaFoldDB; Q54JC6; -.
DR   PaxDb; Q54JC6; -.
DR   EnsemblProtists; EAL63362; EAL63362; DDB_G0288149.
DR   GeneID; 8626479; -.
DR   KEGG; ddi:DDB_G0288149; -.
DR   dictyBase; DDB_G0288149; -.
DR   eggNOG; ENOG502SFK3; Eukaryota.
DR   HOGENOM; CLU_1158177_0_0_1; -.
DR   InParanoid; Q54JC6; -.
DR   OMA; HIRRNIP; -.
DR   PRO; PR:Q54JC6; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019320; BORCS8.
DR   PANTHER; PTHR21146; PTHR21146; 1.
DR   Pfam; PF10167; BORCS8; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..240
FT                   /note="BLOC-1-related complex subunit 8 homolog"
FT                   /id="PRO_0000343675"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          211..239
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        163..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   240 AA;  27210 MW;  870CAEC9CCF165CC CRC64;
     MSSILKSSTG SNHSSTSNHS SINNISQLSG SHGVEQQQLR PVLTLDASTA KLMYQTSQEM
     SSYIQQVANE PTIGLFHVQD HIRRNIPKNV ELKKNIKALG EKIEEKSFDI DYSTKTIKTF
     SEIQTFSNIS SLLQQSIERA NKLVNNKSLL FVNSQMAAPS SSKTFSSFQQ QHKIYQQQQT
     NLTPSKPTLS NDKTNDNNNN NNNLNFVEKI EKEEKIEKED EGKEKDEKEK DDKDLNEKIN