BORC8_DROME
ID BORC8_DROME Reviewed; 183 AA.
AC Q8IR45;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=BLOC-1-related complex subunit 8 homolog {ECO:0000305};
GN ORFNames=CG32590 {ECO:0000312|FlyBase:FBgn0052590};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May participate in the coupling of lysosomes to microtubule
CC plus-end-directed kinesin motor. {ECO:0000250|UniProtKB:Q96FH0}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96FH0}.
CC -!- SIMILARITY: Belongs to the BORCS8 family. {ECO:0000305}.
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DR EMBL; AE014298; AAN09342.1; -; Genomic_DNA.
DR EMBL; BT025828; ABF85728.1; -; mRNA.
DR RefSeq; NP_727796.1; NM_167414.3.
DR AlphaFoldDB; Q8IR45; -.
DR SMR; Q8IR45; -.
DR STRING; 7227.FBpp0073805; -.
DR PaxDb; Q8IR45; -.
DR PRIDE; Q8IR45; -.
DR DNASU; 318103; -.
DR EnsemblMetazoa; FBtr0073988; FBpp0073805; FBgn0052590.
DR GeneID; 318103; -.
DR KEGG; dme:Dmel_CG32590; -.
DR UCSC; CG32590-RA; d. melanogaster.
DR FlyBase; FBgn0052590; CG32590.
DR VEuPathDB; VectorBase:FBgn0052590; -.
DR eggNOG; KOG4523; Eukaryota.
DR GeneTree; ENSGT00390000014856; -.
DR HOGENOM; CLU_1588402_0_0_1; -.
DR InParanoid; Q8IR45; -.
DR OMA; CYDVEYA; -.
DR OrthoDB; 1473909at2759; -.
DR PhylomeDB; Q8IR45; -.
DR BioGRID-ORCS; 318103; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 318103; -.
DR PRO; PR:Q8IR45; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0052590; Expressed in eye disc (Drosophila) and 22 other tissues.
DR Genevisible; Q8IR45; DM.
DR GO; GO:0099078; C:BORC complex; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019320; BORCS8.
DR PANTHER; PTHR21146; PTHR21146; 1.
DR Pfam; PF10167; BORCS8; 1.
PE 2: Evidence at transcript level;
KW Lysosome; Membrane; Reference proteome.
FT CHAIN 1..183
FT /note="BLOC-1-related complex subunit 8 homolog"
FT /id="PRO_0000286447"
FT REGION 152..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 183 AA; 20937 MW; 0AE18C98F0D365FD CRC64;
MSRGNELVFK AKKTSEKISE NIHIFANDPS LAFFRVQEHV RKVTPAIFEK RDEVFQLQNN
LQGHCYDMEY GIQALRTIEK SESIFENIQE MIKASIFLKQ QLKYEESRKK VKKDSTKSSV
YKRFSAHLAL DLPDLPDFGG VMRETSQRME NMIGPGTATG RTEAQAATSS NPGELQRSYT
TLH
