ID   BORC8_MOUSE             Reviewed;         120 AA.
AC   Q9D6Y4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=BLOC-1-related complex subunit 8 {ECO:0000305};
GN   Name=Borcs8 {ECO:0000312|MGI:MGI:1919618};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96FH0}.
CC   -!- SIMILARITY: Belongs to the BORCS8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK009829; BAB26528.1; -; mRNA.
DR   CCDS; CCDS52568.1; -.
DR   RefSeq; NP_001139024.1; NM_001145552.2.
DR   RefSeq; NP_001296770.1; NM_001309841.1.
DR   AlphaFoldDB; Q9D6Y4; -.
DR   SMR; Q9D6Y4; -.
DR   ComplexPortal; CPX-5061; BORC complex.
DR   STRING; 10090.ENSMUSP00000002418; -.
DR   iPTMnet; Q9D6Y4; -.
DR   PhosphoSitePlus; Q9D6Y4; -.
DR   MaxQB; Q9D6Y4; -.
DR   PRIDE; Q9D6Y4; -.
DR   ProteomicsDB; 273698; -.
DR   Antibodypedia; 47987; 92 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000002418; ENSMUSP00000002418; ENSMUSG00000002345.
DR   GeneID; 72368; -.
DR   KEGG; mmu:72368; -.
DR   UCSC; uc009lyy.1; mouse.
DR   CTD; 729991; -.
DR   MGI; MGI:1919618; Borcs8.
DR   VEuPathDB; HostDB:ENSMUSG00000002345; -.
DR   eggNOG; KOG4523; Eukaryota.
DR   GeneTree; ENSGT00390000014856; -.
DR   HOGENOM; CLU_151479_0_0_1; -.
DR   InParanoid; Q9D6Y4; -.
DR   OMA; INIRDHM; -.
DR   OrthoDB; 1473909at2759; -.
DR   TreeFam; TF313931; -.
DR   BioGRID-ORCS; 72368; 2 hits in 25 CRISPR screens.
DR   PRO; PR:Q9D6Y4; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9D6Y4; protein.
DR   Bgee; ENSMUSG00000002345; Expressed in lip and 190 other tissues.
DR   ExpressionAtlas; Q9D6Y4; baseline and differential.
DR   Genevisible; Q9D6Y4; MM.
DR   GO; GO:0099078; C:BORC complex; ISS:UniProtKB.
DR   GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; IC:ComplexPortal.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0032418; P:lysosome localization; IC:ComplexPortal.
DR   GO; GO:0072384; P:organelle transport along microtubule; IC:ComplexPortal.
DR   GO; GO:0051036; P:regulation of endosome size; IC:ComplexPortal.
DR   GO; GO:0062196; P:regulation of lysosome size; IC:ComplexPortal.
DR   InterPro; IPR019320; BORCS8.
DR   PANTHER; PTHR21146; PTHR21146; 1.
DR   Pfam; PF10167; BORCS8; 1.
PE   1: Evidence at protein level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..120
FT                   /note="BLOC-1-related complex subunit 8"
FT                   /id="PRO_0000269844"
FT   REGION          101..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         109
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96FH0"
SQ   SEQUENCE   120 AA;  13565 MW;  CA3AB69B95AC0583 CRC64;
     MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK ADMQRWEEQS
     QGAIYTVEYA CSAVKSLVDS SVYFRSVEGL LKQAISIRDH MNTSAQGHSQ EKLSPPPSLA