ID   BORE1_CHICK             Reviewed;         298 AA.
AC   P86346;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Borealin {ECO:0000250|UniProtKB:Q3KPK4};
DE   AltName: Full=Cell division cycle-associated protein 8 {ECO:0000250|UniProtKB:Q3KPK4};
DE   AltName: Full=Dasra-B {ECO:0000303|PubMed:15260989};
DE            Short=GgDasraB {ECO:0000303|PubMed:15260989};
GN   Name=CDCA8 {ECO:0000250|UniProtKB:Q3KPK4};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=White Leghorn Hisex {ECO:0000269|PubMed:12445392};
RC   TISSUE=Embryo {ECO:0000269|PubMed:12445392};
RX   PubMed=12445392; DOI=10.1016/s0960-9822(02)01296-4;
RA   Boardman P.E., Sanz-Ezquerro J., Overton I.M., Burt D.W., Bosch E.,
RA   Fong W.T., Tickle C., Brown W.R., Wilson S.A., Hubbard S.J.;
RT   "A comprehensive collection of chicken cDNAs.";
RL   Curr. Biol. 12:1965-1969(2002).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=15260989; DOI=10.1016/j.cell.2004.06.026;
RA   Sampath S.C., Ohi R., Leismann O., Salic A., Pozniakovski A., Funabiki H.;
RT   "The chromosomal passenger complex is required for chromatin-induced
RT   microtubule stabilization and spindle assembly.";
RL   Cell 118:187-202(2004).
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly (By similarity).
CC       {ECO:0000250|UniProtKB:Q3KPK4}.
CC   -!- SUBUNIT: Component of the CPC complex. {ECO:0000250|UniProtKB:Q3KPK4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3KPK4}.
CC       Chromosome, centromere {ECO:0000250|UniProtKB:Q3KPK4}. Note=Localizes
CC       on chromosome arms and inner centromeres from prophase through
CC       metaphase and then transferring to the spindle midzone and midbody from
CC       anaphase through cytokinesis. {ECO:0000250|UniProtKB:Q3KPK4}.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000255}.
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DR   EMBL; BU135762; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P86346; -.
DR   SMR; P86346; -.
DR   STRING; 9031.ENSGALP00000034917; -.
DR   VEuPathDB; HostDB:LOC121107213; -.
DR   eggNOG; ENOG502QS4S; Eukaryota.
DR   InParanoid; P86346; -.
DR   PhylomeDB; P86346; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   InterPro; IPR018851; Borealin_N.
DR   InterPro; IPR018867; Cell_div_borealin.
DR   Pfam; PF10512; Borealin; 1.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..298
FT                   /note="Borealin"
FT                   /id="PRO_0000397221"
FT   REGION          145..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..161
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  32578 MW;  80EC27AE45F74C95 CRC64;
     MAPARRKAAA GARGRKLSAF LKDFDREVRS RVEQLRTNGE RLVKEMENLY DVELLRLPAA
     LREMNWLEFF AKGGSQKVVE EAVTADLGIT EINKLTAELI QTPLKIVTKE KSKQGIEATE
     EAAEVPLLPP AKKAKHDSQL LLEQAAASTN PRNGKVRTST KKAPVSRSRR APSARVKRVS
     KRSSKSSFIT PATGRNLDLC ARGGASIVTP RFDSRVFKTP GLRTPAVNER VYTISANGSP
     LADGMMSSLP FLLGGGESIR LTASDLTKKN LLHLNPEGRG IMQKLSVRLC TSLYSAKT