ID   BORE1_DANRE             Reviewed;         276 AA.
AC   Q5XLR4; Q5U3V2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Borealin;
DE   AltName: Full=Cell division cycle-associated protein 8;
DE   AltName: Full=Dasra-B;
DE            Short=DasraB;
DE            Short=DrDasraB;
GN   Name=cdca8; Synonyms=cdca8l; ORFNames=zgc:101607;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=15260989; DOI=10.1016/j.cell.2004.06.026;
RA   Sampath S.C., Ohi R., Leismann O., Salic A., Pozniakovski A., Funabiki H.;
RT   "The chromosomal passenger complex is required for chromatin-induced
RT   microtubule stabilization and spindle assembly.";
RL   Cell 118:187-202(2004).
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CPC complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC       Note=Localizes on chromosome arms and inner centromeres from prophase
CC       through metaphase and then transferring to the spindle midzone and
CC       midbody from anaphase through cytokinesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000305}.
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DR   EMBL; AY751743; AAV28474.1; -; mRNA.
DR   EMBL; BC085383; AAH85383.1; -; mRNA.
DR   RefSeq; NP_001007457.1; NM_001007456.1.
DR   AlphaFoldDB; Q5XLR4; -.
DR   SMR; Q5XLR4; -.
DR   STRING; 7955.ENSDARP00000063336; -.
DR   PaxDb; Q5XLR4; -.
DR   GeneID; 492815; -.
DR   KEGG; dre:492815; -.
DR   CTD; 55143; -.
DR   ZFIN; ZDB-GENE-041114-171; cdca8.
DR   eggNOG; ENOG502QS4S; Eukaryota.
DR   InParanoid; Q5XLR4; -.
DR   PhylomeDB; Q5XLR4; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q5XLR4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   InterPro; IPR018851; Borealin_N.
DR   InterPro; IPR018867; Cell_div_borealin.
DR   Pfam; PF10512; Borealin; 1.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Borealin"
FT                   /id="PRO_0000247079"
FT   REGION          111..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        149
FT                   /note="T -> A (in Ref. 1; AAV28474)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   276 AA;  30382 MW;  18A37C83B9243652 CRC64;
     MAPRKRTQNA KSKKNPKAPK LEAFLLDFDD EVHTIVERLK EKTNNLLKDA DNLYKTALIK
     LPMAVRKMNW IEYCNLEKPK SPVDDSKVRE EAAQVELAIA GNHTIPKVAA KEAKSSANSE
     DENMAPLKST MKKKKASKKA PSTSKKPRTL SISKQGGTIQ RTTRKPLITP ARSFLDSSII
     GATPLITPRF DPRLPKTPAL RSALHREKVY SMSVNGSPLS AGGEDIVISV PIGNGECIQL
     LASEMDSVDL SQLDEKALRS IRNLQNRLTT LCGSSK