ID   BORE1_XENLA             Reviewed;         280 AA.
AC   Q3KPK4; Q693P2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Borealin;
DE   AltName: Full=Cell division cycle-associated protein 8;
DE   AltName: Full=Dasra-B;
DE            Short=DasraB;
DE            Short=xDasraB;
GN   Name=cdca8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION
RP   IN A COMPLEX WITH INCENP, AND IDENTIFICATION IN A COMPLEX WITH CDCA9.
RC   TISSUE=Egg;
RX   PubMed=15260989; DOI=10.1016/j.cell.2004.06.026;
RA   Sampath S.C., Ohi R., Leismann O., Salic A., Pozniakovski A., Funabiki H.;
RT   "The chromosomal passenger complex is required for chromatin-induced
RT   microtubule stabilization and spindle assembly.";
RL   Cell 118:187-202(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, INTERACTION WITH INCENP, AND IDENTIFICATION IN A COMPLEX WITH
RP   AURKB; INCENP; CDCA9; BIRC5.1 AND BIRC5.2.
RX   PubMed=17199039; DOI=10.1016/j.devcel.2006.11.001;
RA   Kelly A.E., Sampath S.C., Maniar T.A., Woo E.M., Chait B.T., Funabiki H.;
RT   "Chromosomal enrichment and activation of the aurora B pathway are coupled
RT   to spatially regulate spindle assembly.";
RL   Dev. Cell 12:31-43(2007).
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly. Contributes to CPC
CC       function by facilitating loading of the CPC onto chromosomes.
CC       {ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:17199039}.
CC   -!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
CC       incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B.
CC       Interacts with incenp (via N-terminus). {ECO:0000269|PubMed:15260989,
CC       ECO:0000269|PubMed:17199039}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15260989}.
CC       Chromosome, centromere {ECO:0000269|PubMed:15260989}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000269|PubMed:15260989}. Note=Localizes on
CC       chromosome arms and inner centromeres from prophase through metaphase
CC       and then transferring to the spindle midzone and midbody from anaphase
CC       through cytokinesis.
CC   -!- MISCELLANEOUS: Was named 'Dasra' in reference to the Hindu mythological
CC       deity Dasra, who acts as a harbinger of the dawn.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT77776.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY644401; AAT77776.1; ALT_INIT; mRNA.
DR   EMBL; BC106697; AAI06698.1; -; mRNA.
DR   RefSeq; NP_001086416.1; NM_001092947.2.
DR   AlphaFoldDB; Q3KPK4; -.
DR   SMR; Q3KPK4; -.
DR   BioGRID; 103012; 1.
DR   DNASU; 444884; -.
DR   GeneID; 444884; -.
DR   KEGG; xla:444884; -.
DR   CTD; 444884; -.
DR   Xenbase; XB-GENE-946933; cdca8.L.
DR   OrthoDB; 1587028at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 444884; Expressed in egg cell and 17 other tissues.
DR   GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR   GO; GO:0032133; C:chromosome passenger complex; IPI:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR018851; Borealin_N.
DR   InterPro; IPR018867; Cell_div_borealin.
DR   Pfam; PF10512; Borealin; 1.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..280
FT                   /note="Borealin"
FT                   /id="PRO_0000247081"
FT   REGION          140..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        3
FT                   /note="S -> P (in Ref. 1; AAT77776)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9
FT                   /note="S -> I (in Ref. 1; AAT77776)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   280 AA;  30934 MW;  CF5BFB25475A2EA7 CRC64;
     MASGKKKTSR KPKNRSVKNE KLASFIKDFD SQVKIITEEM KASVVNILKE VDSQYNIEII
     KLPMAIREMC WLDYIAKGGS QKALEAAATV KVDMEEITST VTKTPFKADK KVKKGKCKPD
     DETVELNPLK SVIRTKTKAK VAAKKPSTAR RTRASVGNVA NTSKRTSKRG RATPSASKQA
     ETSLLGYTPA ATPRIDTSIF KTPALRTPCM QEPVYTFSAN GSPLAGMDEL FINVPARDGK
     IIRLLASEVD GLDINRLDQQ AFENIKLLSS RLERLCKKLK