ID   BORE1_XENTR             Reviewed;         279 AA.
AC   Q6GLC7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Borealin;
DE   AltName: Full=Cell division cycle-associated protein 8;
DE   AltName: Full=Dasra-B;
GN   Name=cdca8;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly. Contributes to CPC
CC       function by facilitating loading of the CPC onto chromosomes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
CC       incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B.
CC       Interacts with incenp (via N-terminus) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC       Note=Localizes on chromosome arms and inner centromeres from prophase
CC       through metaphase and then transferring to the spindle midzone and
CC       midbody from anaphase through cytokinesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000305}.
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DR   EMBL; BC074572; AAH74572.1; -; mRNA.
DR   RefSeq; NP_001002902.1; NM_001002902.1.
DR   RefSeq; XP_012812148.1; XM_012956694.2.
DR   RefSeq; XP_017946645.1; XM_018091156.1.
DR   AlphaFoldDB; Q6GLC7; -.
DR   SMR; Q6GLC7; -.
DR   PRIDE; Q6GLC7; -.
DR   DNASU; 444885; -.
DR   Ensembl; ENSXETT00000004624; ENSXETP00000004624; ENSXETG00000002167.
DR   GeneID; 444885; -.
DR   KEGG; xtr:444885; -.
DR   CTD; 55143; -.
DR   Xenbase; XB-GENE-946929; cdca8.
DR   InParanoid; Q6GLC7; -.
DR   OrthoDB; 1587028at2759; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002167; Expressed in egg cell and 10 other tissues.
DR   ExpressionAtlas; Q6GLC7; baseline.
DR   GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   InterPro; IPR018851; Borealin_N.
DR   InterPro; IPR018867; Cell_div_borealin.
DR   Pfam; PF10512; Borealin; 1.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..279
FT                   /note="Borealin"
FT                   /id="PRO_0000247082"
FT   REGION          135..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   279 AA;  30880 MW;  E48F1C4FF8191078 CRC64;
     MAPTKKKTSR KPKNRCVKNE KLASFIKDFD SQVKIITEEL KASVVNILKE VDSQYNIEII
     KLPMAIREMC WLDYIAKGGS QKALEAAATV KVDMEEITST VTKTPFKLDK KVKKGKCKSD
     ETLEPNPLQS VIRTKTKAKV AAKKPSTARK TRASTANLTN TSKRTSKRGR ATPSASKQIE
     TSLLGYTPAA TPRIDTSIFK TPALRTPCLQ EPVYTFSANG SPLAGMDELF INVPAGDGKN
     IRLLASEVDS LDINRLDNQA FENIKLLSSQ LQRFCKKLK