ID   BORE2_DANRE             Reviewed;         255 AA.
AC   P86347;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Borealin-2 {ECO:0000250|UniProtKB:Q4V7H8};
DE   AltName: Full=Cell division cycle-associated protein 8.2 {ECO:0000312|ZFIN:ZDB-GENE-090706-4};
DE   AltName: Full=Cell division cycle-associated protein 9 {ECO:0000312|ZFIN:ZDB-GENE-090706-4};
DE   AltName: Full=Dasra-A {ECO:0000303|PubMed:15260989};
DE            Short=DrDasraA {ECO:0000303|PubMed:15260989};
GN   Name=cdca9 {ECO:0000312|ZFIN:ZDB-GENE-090706-4};
GN   Synonyms=cdca8.2 {ECO:0000312|ZFIN:ZDB-GENE-090706-4};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary {ECO:0000269|Ref.1};
RA   Clark M., Johnson S.L., Lehrach H., Lee R., Li F., Marra M., Eddy S.,
RA   Hillier L., Kucaba T., Martin J., Beck C., Wylie T., Underwood K.,
RA   Steptoe M., Theising B., Allen M., Bowers Y., Person B., Swaller T.,
RA   Gibbons M., Pape D., Harvey N., Schurk R., Ritter E., Kohn S., Shin T.,
RA   Jackson Y., Cardenas M., McCann R., Waterston R., Wilson R.;
RT   "WashU Zebrafish EST Project 1998.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=15260989; DOI=10.1016/j.cell.2004.06.026;
RA   Sampath S.C., Ohi R., Leismann O., Salic A., Pozniakovski A., Funabiki H.;
RT   "The chromosomal passenger complex is required for chromatin-induced
RT   microtubule stabilization and spindle assembly.";
RL   Cell 118:187-202(2004).
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly (By similarity).
CC       {ECO:0000250|UniProtKB:Q4V7H8}.
CC   -!- SUBUNIT: Component of the CPC complex. {ECO:0000250|UniProtKB:Q4V7H8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q4V7H8}.
CC       Chromosome, centromere {ECO:0000250|UniProtKB:Q4V7H8}. Note=Localizes
CC       on chromosome arms and inner centromeres from prophase through
CC       metaphase and then transferring to the spindle midzone and midbody from
CC       anaphase through cytokinesis. {ECO:0000250|UniProtKB:Q4V7H8}.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000255}.
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DR   EMBL; BM036885; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BM777478; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P86347; -.
DR   SMR; P86347; -.
DR   STRING; 7955.ENSDARP00000127103; -.
DR   PaxDb; P86347; -.
DR   PRIDE; P86347; -.
DR   ZFIN; ZDB-GENE-090706-4; cdca9.
DR   eggNOG; ENOG502S23P; Eukaryota.
DR   InParanoid; P86347; -.
DR   PhylomeDB; P86347; -.
DR   PRO; PR:P86347; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
DR   GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   InterPro; IPR018851; Borealin_N.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..255
FT                   /note="Borealin-2"
FT                   /id="PRO_0000397223"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   255 AA;  28638 MW;  0B5301F237248267 CRC64;
     MAPRRTRKVS QDSDGQADDQ HSFEQKIRLT KRKELFIQQF EKEAQDRINE MEANLNKLLA
     TVDRVFKIEL MKMPLSLHTT LIKDLMNDDD TSVGEVTMAL KCASPEIQKP LSRKPSKKAL
     NALAGQQRSS SQSKTPIEGQ KKPTKKTLHS SKSTGSLRCA STINAKRTQG RVVKLSDQAN
     ALGVQFRQTS RSVGDELMMA TATIVTSHGE TLFLSEDNKD EINVELLDDA AVNQMRKIKE
     LMDYLCNKVR INNTC