ID   BORE2_XENLA             Reviewed;         296 AA.
AC   Q4V7H8; Q693P3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Borealin-2;
DE   AltName: Full=Cell division cycle-associated protein 8.2;
DE   AltName: Full=Cell division cycle-associated protein 9;
DE   AltName: Full=Dasra-A;
DE            Short=DasraA;
DE            Short=xDasraA;
GN   Name=cdca9; Synonyms=cdca8.2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION
RP   IN A COMPLEX WITH BIRC5.1; INCENP AND AURKB, AND IDENTIFICATION IN A
RP   COMPLEX WITH CDCA8.
RC   TISSUE=Egg;
RX   PubMed=15260989; DOI=10.1016/j.cell.2004.06.026;
RA   Sampath S.C., Ohi R., Leismann O., Salic A., Pozniakovski A., Funabiki H.;
RT   "The chromosomal passenger complex is required for chromatin-induced
RT   microtubule stabilization and spindle assembly.";
RL   Cell 118:187-202(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, INTERACTION WITH INCENP, AND IDENTIFICATION IN A COMPLEX WITH
RP   AURKB; INCENP; CDCA8; BIRC5.1 AND BIRC5.2.
RX   PubMed=17199039; DOI=10.1016/j.devcel.2006.11.001;
RA   Kelly A.E., Sampath S.C., Maniar T.A., Woo E.M., Chait B.T., Funabiki H.;
RT   "Chromosomal enrichment and activation of the aurora B pathway are coupled
RT   to spatially regulate spindle assembly.";
RL   Dev. Cell 12:31-43(2007).
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly. Contributes to CPC
CC       function by facilitating loading of the CPC onto chromosomes.
CC       {ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:17199039}.
CC   -!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
CC       incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B.
CC       Interacts with incenp (via N-terminus). {ECO:0000269|PubMed:15260989,
CC       ECO:0000269|PubMed:17199039}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15260989}.
CC       Chromosome, centromere {ECO:0000269|PubMed:15260989}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000269|PubMed:15260989}. Note=Localizes on
CC       chromosome arms and inner centromeres from prophase through metaphase
CC       and then transferring to the spindle midzone and midbody from anaphase
CC       through cytokinesis.
CC   -!- MISCELLANEOUS: Was named 'Dasra' in reference to the Hindu mythological
CC       deity Dasra, who acts as a harbinger of the dawn.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000305}.
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DR   EMBL; AY644400; AAT77775.1; -; mRNA.
DR   EMBL; BC097903; AAH97903.1; -; mRNA.
DR   RefSeq; NP_001086415.1; NM_001092946.1.
DR   AlphaFoldDB; Q4V7H8; -.
DR   SMR; Q4V7H8; -.
DR   BioGRID; 103011; 2.
DR   DNASU; 444883; -.
DR   GeneID; 444883; -.
DR   KEGG; xla:444883; -.
DR   CTD; 444883; -.
DR   Xenbase; XB-GENE-5865093; cdca9.S.
DR   OrthoDB; 1338969at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 444883; Expressed in egg cell and 8 other tissues.
DR   GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR   GO; GO:0032133; C:chromosome passenger complex; IPI:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0051225; P:spindle assembly; IMP:UniProtKB.
DR   InterPro; IPR018851; Borealin_N.
DR   InterPro; IPR018867; Cell_div_borealin.
DR   Pfam; PF10512; Borealin; 1.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..296
FT                   /note="Borealin-2"
FT                   /id="PRO_0000247080"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        150
FT                   /note="T -> A (in Ref. 1; AAT77775)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        210
FT                   /note="T -> I (in Ref. 1; AAT77775)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   296 AA;  32372 MW;  C8D864C1BF2C27D0 CRC64;
     MPPKRNRNRL GTRGEGSGDS GVGMFERNDA VQEHKKEKIR LFMQDFVQQG KDRLAELKKD
     LESLSTTADK ALEVELLKMP LAIRHMKVQD YLSLMGGDKS AVAAAAVKLD CSVDELSEPK
     LVRKNSKKVK VTTNVEYQDD VRTKVMTTST KNRTVQKVPK SKSMLSLTGK NGKKTTALTR
     SVSATPLDKA SKKLLVTNSS SKPAQRSSRT AMTPLTRSAR SDTMFTFGDG AFLDEGVPFV
     KIPLADGKTV FSAGDDLDSL NVELLRGDTV QHIHNLVGQL TSLCAKASIQ HHGNTL