ID   BORE2_XENTR             Reviewed;         296 AA.
AC   Q0V9F7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Borealin-2 {ECO:0000250|UniProtKB:Q4V7H8};
DE   AltName: Full=Cell division cycle-associated protein 8.2;
DE   AltName: Full=Cell division cycle-associated protein 9;
DE   AltName: Full=Dasra-A {ECO:0000250|UniProtKB:Q4V7H8};
GN   Name=cdca9; Synonyms=cdca8.2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI21591.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000312|EMBL:AAI21591.1};
RC   TISSUE=Ovary {ECO:0000312|EMBL:AAI21591.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC       complex that acts as a key regulator of mitosis. The CPC complex has
CC       essential functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly. Contributes to CPC
CC       function by facilitating loading of the CPC onto chromosomes (By
CC       similarity). {ECO:0000250|UniProtKB:Q4V7H8}.
CC   -!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
CC       incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B
CC       Interacts with incenp (via N-terminus). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q4V7H8}.
CC       Chromosome, centromere {ECO:0000250|UniProtKB:Q4V7H8}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}. Note=Localizes on chromosome arms
CC       and inner centromeres from prophase through metaphase and then
CC       transfers to the spindle midzone and midbody from anaphase through
CC       cytokinesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the borealin family. {ECO:0000255}.
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DR   EMBL; BC121590; AAI21591.1; -; mRNA.
DR   RefSeq; NP_001072393.1; NM_001078925.1.
DR   AlphaFoldDB; Q0V9F7; -.
DR   SMR; Q0V9F7; -.
DR   PaxDb; Q0V9F7; -.
DR   DNASU; 779847; -.
DR   GeneID; 779847; -.
DR   KEGG; xtr:779847; -.
DR   CTD; 100151622; -.
DR   Xenbase; XB-GENE-5865000; cdca9.
DR   eggNOG; ENOG502S23P; Eukaryota.
DR   HOGENOM; CLU_090531_0_0_1; -.
DR   InParanoid; Q0V9F7; -.
DR   OrthoDB; 1338969at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003906; Expressed in ovary and 9 other tissues.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.
DR   GO; GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR018851; Borealin_N.
DR   InterPro; IPR018867; Cell_div_borealin.
DR   Pfam; PF10512; Borealin; 1.
DR   Pfam; PF10444; Nbl1_Borealin_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..296
FT                   /note="Borealin-2"
FT                   /id="PRO_0000382235"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  32323 MW;  4630D47392E3B1AE CRC64;
     MPPKRNRKRL GTRGEGSGDS GVGMFERNDA VQEQKKEKIR LFMQDFVQQG KDRLAELKKD
     LESLSTTADK ALEVELLKMP LAIRHMKVQD YLSLMGGDKT AVAAAAVKLD CSVDELSEPK
     LVRKSSKKVK VTTNVEYQDD IRTKVMTTTG KTRTVQKVPK SKSMLSLTGK NSKKTTALTR
     SVSATPIDKA SKKLLVTNSS SKPAQRSSRT AMTPLSRSAR SDAVFSFGDG TFLDEGVPFV
     KIPLADGQTV FSAGDDLDSL NVELLRGDTV QHIHNLVGQL TNLCAKASIQ QHGNTL