ID   BORG1_BOVIN             Reviewed;         210 AA.
AC   Q08DN6;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Cdc42 effector protein 2;
DE   AltName: Full=Binder of Rho GTPases 1;
GN   Name=CDC42EP2; Synonyms=BORG1, CEP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in the organization of the actin
CC       cytoskeleton. May act downstream of CDC42 to induce actin filament
CC       assembly leading to cell shape changes. Induces pseudopodia formation
CC       in fibroblasts in a CDC42-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDC42 and RHOQ, in a GTP-dependent manner, and
CC       with SEPT7. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- DOMAIN: The CRIB domain mediates interaction with CDC42. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BORG/CEP family. {ECO:0000305}.
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DR   EMBL; BC123647; AAI23648.1; -; mRNA.
DR   RefSeq; NP_001068809.1; NM_001075341.1.
DR   AlphaFoldDB; Q08DN6; -.
DR   STRING; 9913.ENSBTAP00000042899; -.
DR   PaxDb; Q08DN6; -.
DR   Ensembl; ENSBTAT00000045518; ENSBTAP00000042899; ENSBTAG00000032089.
DR   GeneID; 507966; -.
DR   KEGG; bta:507966; -.
DR   CTD; 10435; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032089; -.
DR   VGNC; VGNC:27073; CDC42EP2.
DR   eggNOG; ENOG502RY28; Eukaryota.
DR   GeneTree; ENSGT00940000161776; -.
DR   HOGENOM; CLU_073229_0_0_1; -.
DR   InParanoid; Q08DN6; -.
DR   OMA; DQDLGHM; -.
DR   OrthoDB; 1244464at2759; -.
DR   TreeFam; TF331725; -.
DR   Reactome; R-BTA-9013406; RHOQ GTPase cycle.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000032089; Expressed in pons and 99 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IBA:GO_Central.
DR   GO; GO:0031274; P:positive regulation of pseudopodium assembly; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   InterPro; IPR029273; Cdc42_effect.
DR   InterPro; IPR017363; Cdc42_effector_prot_2.
DR   InterPro; IPR000095; CRIB_dom.
DR   Pfam; PF14957; BORG_CEP; 2.
DR   Pfam; PF00786; PBD; 1.
DR   PIRSF; PIRSF038036; Cdc42_effector_p2; 1.
DR   SMART; SM00285; PBD; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell shape; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O14613"
FT   CHAIN           2..210
FT                   /note="Cdc42 effector protein 2"
FT                   /id="PRO_0000394513"
FT   DOMAIN          30..44
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT   REGION          124..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:O14613"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O14613"
FT   MOD_RES         101
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5PQP4"
FT   MOD_RES         141
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O14613"
SQ   SEQUENCE   210 AA;  22496 MW;  B81070A70FA97B9D CRC64;
     MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGND TFGDISFLQG
     KFHLLPGTAV DETQEDSGFE MPFQFTRTAT LCGRELPDGP SPLLKNAISL PVIGGPQALT
     LPAAQAPPKP PRLHLETPQA SPQEAGTVDV WRIPEAGAAH SELTTESGAE EPFLSHASSL
     LSLHVDLGPS ILDDVLQIMD QDLGHLQIPT