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BORG3_HUMAN
ID   BORG3_HUMAN             Reviewed;         148 AA.
AC   Q6NZY7; B0VJZ2; Q8TB51;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Cdc42 effector protein 5;
DE   AltName: Full=Binder of Rho GTPases 3;
GN   Name=CDC42EP5; Synonyms=BORG3, CEP5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably involved in the organization of the actin
CC       cytoskeleton. May act downstream of CDC42 to induce actin filament
CC       assembly leading to cell shape changes. Induces pseudopodia formation
CC       in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls
CC       septin organization and this effect is negatively regulated by CDC42
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDC42, in a GTP-dependent manner, and with
CC       SEPT7. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- DOMAIN: The CRIB domain mediates interaction with CDC42. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BORG/CEP family. {ECO:0000305}.
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DR   EMBL; CU467002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU207370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471135; EAW72252.1; -; Genomic_DNA.
DR   EMBL; BC024327; AAH24327.1; -; mRNA.
DR   EMBL; BC065910; AAH65910.1; -; mRNA.
DR   CCDS; CCDS12896.1; -.
DR   RefSeq; NP_659494.2; NM_145057.3.
DR   AlphaFoldDB; Q6NZY7; -.
DR   BioGRID; 127125; 6.
DR   IntAct; Q6NZY7; 1.
DR   STRING; 9606.ENSP00000301200; -.
DR   iPTMnet; Q6NZY7; -.
DR   PhosphoSitePlus; Q6NZY7; -.
DR   BioMuta; CDC42EP5; -.
DR   DMDM; 71152342; -.
DR   jPOST; Q6NZY7; -.
DR   MassIVE; Q6NZY7; -.
DR   MaxQB; Q6NZY7; -.
DR   PaxDb; Q6NZY7; -.
DR   PeptideAtlas; Q6NZY7; -.
DR   PRIDE; Q6NZY7; -.
DR   ProteomicsDB; 66800; -.
DR   Antibodypedia; 50438; 81 antibodies from 23 providers.
DR   DNASU; 148170; -.
DR   Ensembl; ENST00000301200.3; ENSP00000301200.2; ENSG00000167617.3.
DR   Ensembl; ENST00000611094.1; ENSP00000484985.1; ENSG00000273622.1.
DR   Ensembl; ENST00000617756.1; ENSP00000484158.1; ENSG00000273633.1.
DR   Ensembl; ENST00000619217.1; ENSP00000479726.1; ENSG00000278444.1.
DR   GeneID; 148170; -.
DR   KEGG; hsa:148170; -.
DR   MANE-Select; ENST00000301200.3; ENSP00000301200.2; NM_145057.4; NP_659494.2.
DR   UCSC; uc002qfz.3; human.
DR   CTD; 148170; -.
DR   DisGeNET; 148170; -.
DR   GeneCards; CDC42EP5; -.
DR   HGNC; HGNC:17408; CDC42EP5.
DR   HPA; ENSG00000167617; Tissue enhanced (prostate).
DR   MIM; 609171; gene.
DR   neXtProt; NX_Q6NZY7; -.
DR   OpenTargets; ENSG00000167617; -.
DR   PharmGKB; PA134989100; -.
DR   VEuPathDB; HostDB:ENSG00000167617; -.
DR   eggNOG; ENOG502S9WH; Eukaryota.
DR   GeneTree; ENSGT00940000162969; -.
DR   HOGENOM; CLU_067835_1_0_1; -.
DR   InParanoid; Q6NZY7; -.
DR   OMA; GVMDKDW; -.
DR   OrthoDB; 1500881at2759; -.
DR   PhylomeDB; Q6NZY7; -.
DR   TreeFam; TF331725; -.
DR   PathwayCommons; Q6NZY7; -.
DR   Reactome; R-HSA-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-HSA-9013148; CDC42 GTPase cycle.
DR   SignaLink; Q6NZY7; -.
DR   BioGRID-ORCS; 148170; 9 hits in 1064 CRISPR screens.
DR   ChiTaRS; CDC42EP5; human.
DR   GenomeRNAi; 148170; -.
DR   Pharos; Q6NZY7; Tbio.
DR   PRO; PR:Q6NZY7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6NZY7; protein.
DR   Bgee; ENSG00000167617; Expressed in mucosa of transverse colon and 90 other tissues.
DR   Genevisible; Q6NZY7; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IPI:UniProtKB.
DR   GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IDA:UniProtKB.
DR   GO; GO:0031274; P:positive regulation of pseudopodium assembly; IDA:UniProtKB.
DR   GO; GO:0008360; P:regulation of cell shape; IDA:UniProtKB.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   InterPro; IPR029273; Cdc42_effect.
DR   InterPro; IPR000095; CRIB_dom.
DR   Pfam; PF14957; BORG_CEP; 1.
DR   Pfam; PF00786; PBD; 1.
DR   SMART; SM00285; PBD; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   2: Evidence at transcript level;
KW   Cell shape; Cytoplasm; Cytoskeleton; Membrane; Methylation;
KW   Reference proteome.
FT   CHAIN           1..148
FT                   /note="Cdc42 effector protein 5"
FT                   /id="PRO_0000212653"
FT   DOMAIN          23..37
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..81
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         38
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z0X0"
FT   CONFLICT        59
FT                   /note="E -> Q (in Ref. 3; AAH24327)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  15207 MW;  48BC1A9B9307CEEC CRC64;
     MPVLKQLGPA QPKKRPDRGA LSISAPLGDF RHTLHVGRGG DAFGDTSFLS RHGGGPPPEP
     RAPPAGAPRS PPPPAVPQSA APSPADPLLS FHLDLGPSML DAVLGVMDAA RPEAAAAKPD
     AEPRPGTQPP QARCRPNADL ELNDVIGL
 
 
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