BORG5_BOVIN
ID BORG5_BOVIN Reviewed; 361 AA.
AC Q17QW1;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Cdc42 effector protein 1;
DE AltName: Full=Binder of Rho GTPases 5;
GN Name=CDC42EP1 {ECO:0000250|UniProtKB:Q00587};
GN Synonyms=BORG5 {ECO:0000250|UniProtKB:Q00587};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:AAI18149.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford {ECO:0000312|EMBL:AAI18149.1};
RC TISSUE=Ascending colon {ECO:0000312|EMBL:AAI18149.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably involved in the organization of the actin
CC cytoskeleton. Induced membrane extensions in fibroblasts (By
CC similarity). {ECO:0000250|UniProtKB:Q00587}.
CC -!- SUBUNIT: Interacts with RHOQ and CDC42, in a GTP-dependent manner.
CC {ECO:0000250|UniProtKB:Q00587}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- DOMAIN: The CRIB domain mediates interaction with CDC42.
CC {ECO:0000250|UniProtKB:Q00587}.
CC -!- SIMILARITY: Belongs to the BORG/CEP family. {ECO:0000255}.
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DR EMBL; BC118148; AAI18149.1; -; mRNA.
DR RefSeq; NP_001068963.1; NM_001075495.1.
DR AlphaFoldDB; Q17QW1; -.
DR STRING; 9913.ENSBTAP00000028798; -.
DR PaxDb; Q17QW1; -.
DR Ensembl; ENSBTAT00000028798; ENSBTAP00000028798; ENSBTAG00000030258.
DR GeneID; 511099; -.
DR KEGG; bta:511099; -.
DR CTD; 11135; -.
DR VEuPathDB; HostDB:ENSBTAG00000030258; -.
DR VGNC; VGNC:27072; CDC42EP1.
DR eggNOG; ENOG502RZ2H; Eukaryota.
DR GeneTree; ENSGT00940000160068; -.
DR HOGENOM; CLU_787446_0_0_1; -.
DR InParanoid; Q17QW1; -.
DR OMA; PRGHCPN; -.
DR OrthoDB; 1244464at2759; -.
DR TreeFam; TF331725; -.
DR Reactome; R-BTA-9013404; RAC2 GTPase cycle.
DR Reactome; R-BTA-9013406; RHOQ GTPase cycle.
DR Reactome; R-BTA-9013408; RHOG GTPase cycle.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000030258; Expressed in urinary bladder and 100 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IBA:GO_Central.
DR GO; GO:0031274; P:positive regulation of pseudopodium assembly; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR029273; Cdc42_effect.
DR InterPro; IPR000095; CRIB_dom.
DR Pfam; PF14957; BORG_CEP; 1.
DR Pfam; PF00786; PBD; 1.
DR SMART; SM00285; PBD; 1.
DR PROSITE; PS50108; CRIB; 1.
PE 2: Evidence at transcript level;
KW Cell shape; Cytoplasm; Cytoskeleton; Membrane; Methylation; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..361
FT /note="Cdc42 effector protein 1"
FT /id="PRO_0000278119"
FT DOMAIN 38..52
FT /note="CRIB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT REPEAT 220..226
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 229..235
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 236..242
FT /note="3"
FT /evidence="ECO:0000255"
FT REPEAT 243..249
FT /note="4"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..249
FT /note="4 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-
FT [PTS]-[AG]"
FT /evidence="ECO:0000255"
FT REGION 320..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..241
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 27
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 34
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q91W92"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91W92"
FT MOD_RES 53
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 139
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91W92"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 190
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 192
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1A5P0"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00587"
SQ SEQUENCE 361 AA; 37334 MW; 85AE4CE083E082AD CRC64;
MPGPQGAGGA PAMNLGKLSP VGWVSSSQGK KRLTADMISP PLGDFRHTMH VGRGGDVFGD
TSFLSNHGGG SGSTHRSPRG FLAKKLQLVR RVGAPPRRMA SPPAPSPAPP AISPIIKNAI
SLPQLNQAAY DSLVVGKLSF DRSPASSTDG HSAYGLDSGF CTISRLPRPE KPRDRDRDSS
FPAEPELRRS DSLLSFRLDL DLGPSLLTEL LGAMSLSEGS AAETPAPAPA ASPPASVANP
PAPASSPSLR GRCPNGVTTR LGPVAEARAS VVGEGPRAPA DEGPGKHRGA VSGGSQSRHH
YTEVDARAEG LGALSQARAS WGSLDEEWGA SQAGSRTPVP STVQANTFEF ADAEEDDEVK
V
