BOSS_DROVI
ID BOSS_DROVI Reviewed; 893 AA.
AC Q24738;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Protein bride of sevenless;
DE Flags: Precursor;
GN Name=boss;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8506350; DOI=10.1073/pnas.90.11.5047;
RA Hart A.C., Harrison S.D., van Vactor D.L. Jr., Rubin G.M., Zipursky S.L.;
RT "The interaction of bride of sevenless with sevenless is conserved between
RT Drosophila virilis and Drosophila melanogaster.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:5047-5051(1993).
CC -!- FUNCTION: Acts as a ligand for sevenless tyrosine-kinase receptor
CC during eye development.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; L08132; AAA72332.1; -; Genomic_DNA.
DR PIR; A47550; A47550.
DR AlphaFoldDB; Q24738; -.
DR STRING; 7244.FBpp0238316; -.
DR PRIDE; Q24738; -.
DR eggNOG; KOG1056; Eukaryota.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0035997; C:rhabdomere microvillus membrane; IEA:EnsemblMetazoa.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0048018; F:receptor ligand activity; IEA:EnsemblMetazoa.
DR GO; GO:0005118; F:sevenless binding; IEA:EnsemblMetazoa.
DR GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0055088; P:lipid homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0045470; P:R8 cell-mediated photoreceptor organization; IEA:EnsemblMetazoa.
DR GO; GO:0009749; P:response to glucose; IEA:EnsemblMetazoa.
DR GO; GO:0045500; P:sevenless signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR002956; Bride_of_7less.
DR InterPro; IPR017978; GPCR_3_C.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01223; BRIDEOF7LESS.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Sensory transduction; Signal; Transducer; Transmembrane;
KW Transmembrane helix; Vision.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..893
FT /note="Protein bride of sevenless"
FT /id="PRO_0000012972"
FT TOPO_DOM 32..530
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 607..627
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 692..712
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 722..742
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 773..893
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 36..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 471
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 482
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 893 AA; 99939 MW; ABB9D4C21DB680C3 CRC64;
MSGLQLIWKS PTQLVLFVLL ITISCIDLCH AVGAATPTKK SPPVRITKPQ PVSSTTTAIP
TTNEGSTTGE QLALLVSSTT EGTASSASSS SNGGSDDSSS TTAAGSLVPE ICITGLQLSF
TNADGEQVVR KQQELVQVIE GDVMLSVITS DPVSALFVIN RVNQANLISA DFEVGIRAIN
VDNASLAENL LIQEVQYLQQ CTQYSMGIFI DFDLYKRLES IIRDLEYNVW PIPSARAHLF
PKVAHLLHQM PWGEKIASVE IVTETLDIYN EFMDAARQEH MCLMHFKSDD NVYILFGNKM
ANHFKENGTV FAVPTERTEH IFLEELPNKS FILMENGIEL RTADLDPMPT TLDEVLIGKS
VLPSRILVFA SPIVDLMNWL RGSLAKHCKR DEDLYMLESC FNFLNFIEDW RTPEYRRTHD
TAELLSLLRM RKLSTSMLFQ MYQKKQETVD VITGESRMEL REIASQNFVT NVTTYYHYNR
DNHTSLELKT KFGLVFNCQF TAGENRRYPF LFDGESVMFW RIKLDTWVAT GLTAAILGLI
ATLAILVFIV VRISLGDVFE GNPVTSILLL LSLILVFCSF VPFSMEYVGE QRNSHVTFED
VHTLNTLCGV RVFIMTLVYC FVFSLLLCRA VMLASIGSEG GFLSHVNGYI QAIICVLSVF
VQVGMSVQLL VVMHLASESV SCENIYYGRW LWGLLAYDFL LLCSLVSLVP FIYRSQRNYR
EGILIVIGAV LILIIWSVWI ALSMFGDEWR DAAIPLGMQA SGWAVLVGIL IPRTFLIVRG
IERSDIAQAL PSLTSLAFAQ NNQYSSEQSV YECVNPAMRH CSQEEMNHQS PSEIPTLPLR
GGGPRRQQFF ANLRQANANI NPQRPPPHPQ QSPSRSSVCS LPPSPDHSKI TRF
