ID   SZ12A_DANRE             Reviewed;         657 AA.
AC   Q6DC03; A7YYE1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Polycomb protein suz12-A;
DE   AltName: Full=Suppressor of zeste 12 protein homolog A;
GN   Name=suz12a; Synonyms=suz12, suz12l; ORFNames=zgc:100863;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC       complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC       to transcriptional repression of the affected target gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
CC       {ECO:0000305}.
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DR   EMBL; BC078293; AAH78293.1; -; mRNA.
DR   EMBL; BC152625; AAI52626.1; -; mRNA.
DR   RefSeq; NP_001003529.1; NM_001003529.2.
DR   AlphaFoldDB; Q6DC03; -.
DR   SMR; Q6DC03; -.
DR   STRING; 7955.ENSDARP00000093727; -.
DR   PaxDb; Q6DC03; -.
DR   GeneID; 794171; -.
DR   KEGG; dre:794171; -.
DR   CTD; 794171; -.
DR   ZFIN; ZDB-GENE-040801-36; suz12a.
DR   eggNOG; KOG2350; Eukaryota.
DR   InParanoid; Q6DC03; -.
DR   OrthoDB; 516359at2759; -.
DR   PhylomeDB; Q6DC03; -.
DR   PRO; PR:Q6DC03; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR019135; Polycomb_protein_VEFS-Box.
DR   Pfam; PF09733; VEFS-Box; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..657
FT                   /note="Polycomb protein suz12-A"
FT                   /id="PRO_0000343752"
FT   ZN_FING         413..436
FT                   /note="C2H2-type"
FT   REGION          335..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..604
FT                   /note="VEFS-box"
FT   COMPBIAS        342..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        252
FT                   /note="H -> R (in Ref. 1; AAI52626)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        360
FT                   /note="I -> V (in Ref. 1; AAI52626)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        392..394
FT                   /note="HVY -> RVC (in Ref. 1; AAI52626)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        411
FT                   /note="D -> E (in Ref. 1; AAI52626)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        447
FT                   /note="P -> S (in Ref. 1; AAI52626)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        657
FT                   /note="H -> D (in Ref. 1; AAI52626)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   657 AA;  75115 MW;  1C36CC44C224E1AB CRC64;
     MAPQKHGSGG NGFYGNSASK AANGGAHASS GVVMTSVKRL KMEQIQADHQ LFLEAFEKPT
     QIYRFLRTRN LITPIFLHRS LTYMSHRNSR TNSKRKSFSL NDLLFKVEKS KVDPESHNLA
     SNLQLTFTGF FHKTEKQLQN SENEENSVSV EVLLVKLCHK KRKDVTCPVK QVPTGKKQVP
     LNPDISPTKL GAFPTLVVPS HEFEPVNSNT VKSYSLLFRA SRPWGREHNG MTTRDTNVIE
     ELSNRKKRYC SHQDDGETTF VAQMTVFDKN RRLQLLDGEY EVSMQEIEES PVGKKRATWE
     TILDEKWVPP FETFSQGPTL QFTLRWTNDT ADKATAPVAK PLATRNSESS TVDSSKTSNI
     KPPQAVAVND SLGTDLPVRR EQTHIEPCQK LHVYYQFLYN NNTRQQTEAR DDLHCPWCTL
     NCRKLYSLLK HLKLSHSRFI FNYVPHPKGA RIDVSINECY DGSYVGNPQD ILCQPGFAFS
     RNGPVKRTPV TQILVCRPKR SKPSLSEFLE PEDGEQEQQR TYISGHNRLY FHSDSCTPLR
     PQEMEVDSED ERDPDWLREK TAMQIEEFTD VNEGEKEIMK LWNLLVMKHG FIADNQMNQA
     CMSFVEQHGT IMVEKNLCRN ALLHLINMHD FGLITTATID KAMTHLRDLT QQSIAQH