ID   SZ12B_DANRE             Reviewed;         682 AA.
AC   B0R1D5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Polycomb protein suz12-B;
DE   AltName: Full=Suppressor of zeste 12 protein homolog B;
GN   Name=suz12b; Synonyms=suz12; ORFNames=si:dkey-10p5.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC       complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC       to transcriptional repression of the affected target gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
CC       {ECO:0000305}.
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DR   EMBL; AL954746; CAQ15133.1; -; Genomic_DNA.
DR   EMBL; BC163026; AAI63026.1; -; mRNA.
DR   RefSeq; NP_001076293.2; NM_001082824.2.
DR   AlphaFoldDB; B0R1D5; -.
DR   SMR; B0R1D5; -.
DR   STRING; 7955.ENSDARP00000068241; -.
DR   PaxDb; B0R1D5; -.
DR   PeptideAtlas; B0R1D5; -.
DR   Ensembl; ENSDART00000165271; ENSDARP00000130332; ENSDARG00000098924.
DR   GeneID; 561871; -.
DR   KEGG; dre:561871; -.
DR   CTD; 561871; -.
DR   ZFIN; ZDB-GENE-030131-3255; suz12b.
DR   eggNOG; KOG2350; Eukaryota.
DR   GeneTree; ENSGT00390000012364; -.
DR   HOGENOM; CLU_014678_0_0_1; -.
DR   InParanoid; B0R1D5; -.
DR   OMA; RNEKMFG; -.
DR   OrthoDB; 516359at2759; -.
DR   PhylomeDB; B0R1D5; -.
DR   TreeFam; TF323249; -.
DR   Reactome; R-DRE-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-DRE-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-DRE-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-DRE-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DRE-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:B0R1D5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000098924; Expressed in retina and 26 other tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR019135; Polycomb_protein_VEFS-Box.
DR   Pfam; PF09733; VEFS-Box; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..682
FT                   /note="Polycomb protein suz12-B"
FT                   /id="PRO_0000343751"
FT   ZN_FING         408..431
FT                   /note="C2H2-type"
FT   REGION          326..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..599
FT                   /note="VEFS-box"
FT   COMPBIAS        334..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  77678 MW;  86445B665585C2B6 CRC64;
     MAPQKYSAQV MNSKANGAVY PSSGVSSLKK PKIEQLQADH ELFLQAFEKP TQIYRFLRTR
     NLITPVLLHR TLTFMSHRNS RTNAKRKSFK VDDLLSSVEK MKGEPESPSL TSHLQLTFTG
     FFHKNVKPCQ NSENEQNSVS LEVLLVKVCH KKRKDVSCPI KQVPTGKKQV PLNPDLSQTK
     PGAFPSLLVS SNEFEPSNSH MVKSYSLLFR VSHTGKRDPN GFISCEADEN IDVKDEIPPR
     RKRNSSLRGD GETTETFVAQ MTVFDKNRRL QLLDGEYEVS MQQIEDCPVS KKRATWETIL
     DGKRLPPFET FSQGPTLQFT LRWTADPSDP STAPVAKPLS TRNSDTSTTE SRISTLRPAP
     VAVKESVSTS MQSRIEHSPC EPRQKLRIFY QFLYNNNTRQ QTEARDDLHC PWCTLNCRKL
     YSLLKHLKLS HSRFIFNYVP HPKGARIDVS INECYDGSYV GNPQDIHSQP GFAFSRNGPV
     KRTAVTHILV CRPKRTKPSL SEFLESEDGE PEQQRTYVSG HNRLYFHSDS CMPLRPQEME
     VDSEDERDPE WLQEKTTTQI EEFTDVNEGE KEVMKLWNLH VMKNGFIADN QMSQASMLFV
     EICGPHIIRR NLCRNFLLHL VNLHDFNLVT IATIDQAMAR LKEIEESFPE LEAGQESLDA
     TCNGHSLSLG FSLHGKCTKL ES