SZRD1_MOUSE
ID SZRD1_MOUSE Reviewed; 152 AA.
AC Q6NXN1; Q3TB72; Q8BT36;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=SUZ domain-containing protein 1;
GN Name=Szrd1; Synonyms=D4Ertd22e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Dendritic cell, Embryo, Placenta, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-39, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NXN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NXN1-2; Sequence=VSP_027998;
CC -!- SIMILARITY: Belongs to the SZRD1 family. {ECO:0000305}.
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DR EMBL; AK027934; BAC25672.1; -; mRNA.
DR EMBL; AK145912; BAE26745.1; -; mRNA.
DR EMBL; AK171420; BAE42442.1; -; mRNA.
DR EMBL; AK171702; BAE42618.1; -; mRNA.
DR EMBL; AL645625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066992; AAH66992.1; -; mRNA.
DR CCDS; CCDS18864.1; -. [Q6NXN1-1]
DR RefSeq; NP_001020779.1; NM_001025608.2. [Q6NXN1-1]
DR RefSeq; NP_001264124.1; NM_001277195.1.
DR AlphaFoldDB; Q6NXN1; -.
DR BioGRID; 229443; 1.
DR STRING; 10090.ENSMUSP00000099545; -.
DR iPTMnet; Q6NXN1; -.
DR PhosphoSitePlus; Q6NXN1; -.
DR EPD; Q6NXN1; -.
DR jPOST; Q6NXN1; -.
DR MaxQB; Q6NXN1; -.
DR PaxDb; Q6NXN1; -.
DR PeptideAtlas; Q6NXN1; -.
DR PRIDE; Q6NXN1; -.
DR ProteomicsDB; 253452; -. [Q6NXN1-1]
DR ProteomicsDB; 253453; -. [Q6NXN1-2]
DR Antibodypedia; 29172; 152 antibodies from 18 providers.
DR Ensembl; ENSMUST00000102487; ENSMUSP00000099545; ENSMUSG00000040842. [Q6NXN1-1]
DR GeneID; 213491; -.
DR KEGG; mmu:213491; -.
DR UCSC; uc008vnw.2; mouse. [Q6NXN1-1]
DR UCSC; uc008vnx.2; mouse. [Q6NXN1-2]
DR CTD; 26099; -.
DR MGI; MGI:1098672; Szrd1.
DR VEuPathDB; HostDB:ENSMUSG00000040842; -.
DR eggNOG; ENOG502RZH5; Eukaryota.
DR GeneTree; ENSGT00390000005532; -.
DR InParanoid; Q6NXN1; -.
DR OMA; DNPGQDR; -.
DR OrthoDB; 1630870at2759; -.
DR PhylomeDB; Q6NXN1; -.
DR TreeFam; TF324643; -.
DR BioGRID-ORCS; 213491; 11 hits in 73 CRISPR screens.
DR ChiTaRS; Szrd1; mouse.
DR PRO; PR:Q6NXN1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q6NXN1; protein.
DR Bgee; ENSMUSG00000040842; Expressed in yolk sac and 224 other tissues.
DR ExpressionAtlas; Q6NXN1; baseline and differential.
DR Genevisible; Q6NXN1; MM.
DR InterPro; IPR024771; SUZ.
DR InterPro; IPR024642; SUZ-C.
DR InterPro; IPR039228; SZRD1.
DR PANTHER; PTHR31796; PTHR31796; 1.
DR Pfam; PF12752; SUZ; 1.
DR Pfam; PF12901; SUZ-C; 1.
DR PROSITE; PS51673; SUZ; 1.
DR PROSITE; PS51938; SUZ_C; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..152
FT /note="SUZ domain-containing protein 1"
FT /id="PRO_0000303069"
FT DOMAIN 42..107
FT /note="SUZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01009"
FT DOMAIN 111..152
FT /note="SUZ-C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01287"
FT REGION 30..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z422"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z422"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z422"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19131326"
FT VAR_SEQ 1..34
FT /note="MEDEEVAESWEEAADSGEIDRRLEKKLKITQKES -> MRRSLRAGRRRQTA
FT G (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027998"
FT CONFLICT 124
FT /note="S -> P (in Ref. 1; BAE42442)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 152 AA; 16998 MW; 3EF639D6A97DE6B1 CRC64;
MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD SLPTGPPPQI
RILKRPTSNG VVSSPNSTSR PALPVKSLAQ REAEYAEARR RILGSASPEE EQEKPILDRP
TRISQPEDSR QPSNVIRQPL GPDGSQGFKQ RR
