ID   T106A_BOVIN             Reviewed;         261 AA.
AC   Q5EA90;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transmembrane protein 106A;
GN   Name=TMEM106A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates macrophages and polarizes them into M1-like
CC       macrophages through the activation of the MAPK and NF-kappaB signaling
CC       pathway. Upon activation, up-regulates the expression of CD80, CD86,
CC       CD69 and MHC II on macrophages, and induces the release of pro-
CC       inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide
CC       (By similarity). May play a role in inhibition of proliferation and
CC       migration (By similarity). {ECO:0000250|UniProtKB:Q8VC04,
CC       ECO:0000250|UniProtKB:Q96A25}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
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DR   EMBL; BT020679; AAX08696.1; -; mRNA.
DR   EMBL; BC114088; AAI14089.1; -; mRNA.
DR   RefSeq; NP_001014870.1; NM_001014870.3.
DR   RefSeq; XP_005220744.1; XM_005220687.3.
DR   RefSeq; XP_005220745.1; XM_005220688.3.
DR   RefSeq; XP_010814526.1; XM_010816224.2.
DR   RefSeq; XP_010814527.1; XM_010816225.2.
DR   AlphaFoldDB; Q5EA90; -.
DR   STRING; 9913.ENSBTAP00000008944; -.
DR   PaxDb; Q5EA90; -.
DR   PRIDE; Q5EA90; -.
DR   Ensembl; ENSBTAT00000008944; ENSBTAP00000008944; ENSBTAG00000006801.
DR   Ensembl; ENSBTAT00000069834; ENSBTAP00000057529; ENSBTAG00000006801.
DR   Ensembl; ENSBTAT00000071059; ENSBTAP00000063987; ENSBTAG00000006801.
DR   GeneID; 508269; -.
DR   KEGG; bta:508269; -.
DR   CTD; 113277; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006801; -.
DR   VGNC; VGNC:35944; TMEM106A.
DR   eggNOG; ENOG502RY0I; Eukaryota.
DR   GeneTree; ENSGT00940000161546; -.
DR   HOGENOM; CLU_089337_1_0_1; -.
DR   InParanoid; Q5EA90; -.
DR   OMA; CSYLCHS; -.
DR   OrthoDB; 1175832at2759; -.
DR   TreeFam; TF328907; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000006801; Expressed in monocyte and 105 other tissues.
DR   ExpressionAtlas; Q5EA90; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0035780; P:CD80 biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0035781; P:CD86 biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042116; P:macrophage activation; ISS:UniProtKB.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR   GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
DR   GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; ISS:UniProtKB.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   InterPro; IPR009790; TMEM106.
DR   PANTHER; PTHR28556; PTHR28556; 1.
DR   Pfam; PF07092; DUF1356; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Immunity; Innate immunity; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..261
FT                   /note="Transmembrane protein 106A"
FT                   /id="PRO_0000242136"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   261 AA;  28828 MW;  9C88EF767C5A5936 CRC64;
     MGETFSQLAS QKDENKLILP PNPAFGSKAA SYSSMGNSRP FFSCVPCERA AGAGFVTCPT
     CQGSGEIPRE LEKQLVALIP YGDQRLKPRH TKLSVFLAVS ICLVTSSLII FFLFPRTIAV
     QPVGLNSSTV ATDEANVYLN ITSILNISNN NYCPITVTQL TIEVLHLSLV VGQVSHSLLL
     HIGPLASEQM FYAVTNRIND ENTYKICTWL EIKVHHVLLY IQGTLTYSYL SRSEQLVFQS
     YEYVDCRGNT SVPHLLVSHP P