T106A_HUMAN
ID T106A_HUMAN Reviewed; 262 AA.
AC Q96A25; A8K2X2; B7Z698;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Transmembrane protein 106A;
GN Name=TMEM106A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Umbilical cord blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=29131025; DOI=10.1159/000484495;
RA Wu C., Xu J., Wang H., Zhang J., Zhong J., Zou X., Chen Y., Yang G.,
RA Zhong Y., Lai D., Li X., Tang A.;
RT "TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer.";
RL Kidney Blood Press. Res. 42:853-864(2017).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=30456879; DOI=10.1002/jcb.28057;
RA Liu J., Zhu H.;
RT "TMEM106A inhibits cell proliferation, migration, and induces apoptosis of
RT lung cancer cells.";
RL J. Cell. Biochem. 0:0-0(2018).
CC -!- FUNCTION: Activates macrophages and polarizes them into M1-like
CC macrophages through the activation of the MAPK and NF-kappaB signaling
CC pathway. Upon activation, up-regulates the expression of CD80, CD86,
CC CD69 and MHC II on macrophages, and induces the release of pro-
CC inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide
CC (By similarity). May play a role in inhibition of proliferation and
CC migration (PubMed:30456879, PubMed:29131025).
CC {ECO:0000250|UniProtKB:Q8VC04, ECO:0000269|PubMed:29131025,
CC ECO:0000269|PubMed:30456879}.
CC -!- INTERACTION:
CC Q96A25; O75355-2: ENTPD3; NbExp=3; IntAct=EBI-3915978, EBI-12279764;
CC Q96A25; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-3915978, EBI-711490;
CC Q96A25; P29033: GJB2; NbExp=3; IntAct=EBI-3915978, EBI-3905204;
CC Q96A25; O14653: GOSR2; NbExp=3; IntAct=EBI-3915978, EBI-4401517;
CC Q96A25; P24593: IGFBP5; NbExp=3; IntAct=EBI-3915978, EBI-720480;
CC Q96A25; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-3915978, EBI-2821497;
CC Q96A25; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-3915978, EBI-12845616;
CC Q96A25; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-3915978, EBI-10694905;
CC Q96A25; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-3915978, EBI-2548832;
CC Q96A25; Q9H2S6-2: TNMD; NbExp=3; IntAct=EBI-3915978, EBI-12003398;
CC Q96A25; O14817: TSPAN4; NbExp=3; IntAct=EBI-3915978, EBI-8652667;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96A25-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96A25-2; Sequence=VSP_056642;
CC -!- TISSUE SPECIFICITY: Expressed in renal cells (at protein level)
CC (PubMed:29131025). Expressed in epithelial cells (PubMed:30456879).
CC {ECO:0000269|PubMed:29131025, ECO:0000269|PubMed:30456879}.
CC -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
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DR EMBL; AK056132; BAB71101.1; -; mRNA.
DR EMBL; AK290387; BAF83076.1; -; mRNA.
DR EMBL; AK299974; BAH13184.1; -; mRNA.
DR EMBL; BC012139; AAH12139.1; -; mRNA.
DR EMBL; BC146974; AAI46975.1; -; mRNA.
DR EMBL; BC146976; AAI46977.1; -; mRNA.
DR EMBL; BC147023; AAI47024.1; -; mRNA.
DR EMBL; AC087365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60954.1; -; Genomic_DNA.
DR EMBL; BC157892; AAI57893.1; -; mRNA.
DR CCDS; CCDS11462.1; -. [Q96A25-1]
DR CCDS; CCDS74073.1; -. [Q96A25-2]
DR RefSeq; NP_001278515.1; NM_001291586.1. [Q96A25-1]
DR RefSeq; NP_001278516.1; NM_001291587.1. [Q96A25-2]
DR RefSeq; NP_659478.1; NM_145041.3. [Q96A25-1]
DR RefSeq; XP_006721721.1; XM_006721658.2.
DR RefSeq; XP_006721722.1; XM_006721659.3.
DR RefSeq; XP_016879603.1; XM_017024114.1.
DR AlphaFoldDB; Q96A25; -.
DR BioGRID; 125240; 242.
DR IntAct; Q96A25; 12.
DR STRING; 9606.ENSP00000483246; -.
DR TCDB; 9.B.23.1.5; the tmem106 (tmem106) family.
DR iPTMnet; Q96A25; -.
DR PhosphoSitePlus; Q96A25; -.
DR BioMuta; TMEM106A; -.
DR DMDM; 74731081; -.
DR jPOST; Q96A25; -.
DR MassIVE; Q96A25; -.
DR MaxQB; Q96A25; -.
DR PaxDb; Q96A25; -.
DR PeptideAtlas; Q96A25; -.
DR PRIDE; Q96A25; -.
DR ProteomicsDB; 6760; -.
DR ProteomicsDB; 75896; -. [Q96A25-1]
DR Antibodypedia; 61733; 64 antibodies from 19 providers.
DR DNASU; 113277; -.
DR Ensembl; ENST00000541594.5; ENSP00000439844.1; ENSG00000184988.8. [Q96A25-2]
DR Ensembl; ENST00000588659.5; ENSP00000466820.1; ENSG00000184988.8. [Q96A25-1]
DR Ensembl; ENST00000612339.4; ENSP00000483246.1; ENSG00000184988.8. [Q96A25-1]
DR GeneID; 113277; -.
DR KEGG; hsa:113277; -.
DR MANE-Select; ENST00000612339.4; ENSP00000483246.1; NM_145041.4; NP_659478.1.
DR UCSC; uc002idn.2; human. [Q96A25-1]
DR CTD; 113277; -.
DR DisGeNET; 113277; -.
DR GeneCards; TMEM106A; -.
DR HGNC; HGNC:28288; TMEM106A.
DR HPA; ENSG00000184988; Tissue enhanced (kidney).
DR neXtProt; NX_Q96A25; -.
DR OpenTargets; ENSG00000184988; -.
DR PharmGKB; PA142670755; -.
DR VEuPathDB; HostDB:ENSG00000184988; -.
DR eggNOG; ENOG502RY0I; Eukaryota.
DR GeneTree; ENSGT00940000161546; -.
DR HOGENOM; CLU_089337_1_0_1; -.
DR InParanoid; Q96A25; -.
DR OMA; CSYLCHS; -.
DR OrthoDB; 1175832at2759; -.
DR PhylomeDB; Q96A25; -.
DR PathwayCommons; Q96A25; -.
DR SignaLink; Q96A25; -.
DR BioGRID-ORCS; 113277; 32 hits in 1081 CRISPR screens.
DR GeneWiki; TMEM106A; -.
DR GenomeRNAi; 113277; -.
DR Pharos; Q96A25; Tbio.
DR PRO; PR:Q96A25; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96A25; protein.
DR Bgee; ENSG00000184988; Expressed in buccal mucosa cell and 168 other tissues.
DR ExpressionAtlas; Q96A25; baseline and differential.
DR Genevisible; Q96A25; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0035780; P:CD80 biosynthetic process; ISS:UniProtKB.
DR GO; GO:0035781; P:CD86 biosynthetic process; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042116; P:macrophage activation; ISS:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
DR GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; ISS:UniProtKB.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR InterPro; IPR009790; TMEM106.
DR PANTHER; PTHR28556; PTHR28556; 1.
DR Pfam; PF07092; DUF1356; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Immunity; Innate immunity; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..262
FT /note="Transmembrane protein 106A"
FT /id="PRO_0000242137"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..49
FT /note="MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCE ->
FT M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056642"
SQ SEQUENCE 262 AA; 28920 MW; 306433230D5E8D8B CRC64;
MGKTFSQLGS WREDENKSIL SSKPAIGSKA VNYSSTGSSK SFCSCVPCEG TADASFVTCP
TCQGSGKIPQ ELEKQLVALI PYGDQRLKPK HTKLFVFLAV LICLVTSSFI VFFLFPRSVI
VQPAGLNSST VAFDEADIYL NITNILNISN GNYYPIMVTQ LTLEVLHLSL VVGQVSNNLL
LHIGPLASEQ MFYAVATKIR DENTYKICTW LEIKVHHVLL HIQGTLTCSY LSHSEQLVFQ
SYEYVDCRGN ASVPHQLTPH PP
