ID   T106A_RAT               Reviewed;         261 AA.
AC   Q5BK83;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Transmembrane protein 106A;
GN   Name=Tmem106a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Activates macrophages and polarizes them into M1-like
CC       macrophages through the activation of the MAPK and NF-kappaB signaling
CC       pathway. Upon activation, up-regulates the expression of CD80, CD86,
CC       CD69 and MHC II on macrophages, and induces the release of pro-
CC       inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide
CC       (By similarity). May play a role in inhibition of proliferation and
CC       migration (By similarity). {ECO:0000250|UniProtKB:Q8VC04,
CC       ECO:0000250|UniProtKB:Q96A25}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
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DR   EMBL; BC091170; AAH91170.1; -; mRNA.
DR   RefSeq; NP_001020138.1; NM_001024967.1.
DR   AlphaFoldDB; Q5BK83; -.
DR   SMR; Q5BK83; -.
DR   STRING; 10116.ENSRNOP00000036228; -.
DR   iPTMnet; Q5BK83; -.
DR   PhosphoSitePlus; Q5BK83; -.
DR   PaxDb; Q5BK83; -.
DR   GeneID; 287722; -.
DR   KEGG; rno:287722; -.
DR   UCSC; RGD:1309043; rat.
DR   CTD; 113277; -.
DR   RGD; 1309043; Tmem106a.
DR   VEuPathDB; HostDB:ENSRNOG00000023628; -.
DR   eggNOG; ENOG502RY0I; Eukaryota.
DR   HOGENOM; CLU_089337_1_0_1; -.
DR   InParanoid; Q5BK83; -.
DR   OMA; CSYLCHS; -.
DR   OrthoDB; 1175832at2759; -.
DR   PhylomeDB; Q5BK83; -.
DR   TreeFam; TF328907; -.
DR   PRO; PR:Q5BK83; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000023628; Expressed in kidney and 19 other tissues.
DR   Genevisible; Q5BK83; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0035780; P:CD80 biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0035781; P:CD86 biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042116; P:macrophage activation; ISS:UniProtKB.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR   GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
DR   GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; ISS:UniProtKB.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   InterPro; IPR009790; TMEM106.
DR   PANTHER; PTHR28556; PTHR28556; 1.
DR   Pfam; PF07092; DUF1356; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Immunity; Innate immunity; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..261
FT                   /note="Transmembrane protein 106A"
FT                   /id="PRO_0000242139"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29136 MW;  9E1CF0D8BFAAC441 CRC64;
     MGKAFSQLTS QKDEDKSILP DNPAMASKAA NYFSTGNRKP SHSCVPCEKA ASTSFVTCPT
     CQGNGEIPQE LEKQLVALIP YGDQRLKPRR TKLSVFLAVT ICLLIFSLTI FFLYPRNIVV
     HPVGLNSSTV AFDETHVQLN MTNVLNITNS NFYPVTVTQL TAEVLHQTSV VGQVTSSLRL
     HIGPLASKQM PYEVASRILD ENTYKICTWP KIRVHHILVN IQGALTCSYL THPQQLPFES
     FEYVDCRENM SMPHLELPRP A