ID   T106B_BOVIN             Reviewed;         275 AA.
AC   Q3ZC25;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Transmembrane protein 106B;
GN   Name=TMEM106B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in dendrite morphogenesis and maintenance by
CC       regulating lysosomal trafficking via its interaction with MAP6. May act
CC       by inhibiting retrograde transport of lysosomes along dendrites.
CC       Required for dendrite branching (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MAP6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Single-pass
CC       type II membrane protein. Lysosome membrane {ECO:0000250}; Single-pass
CC       type II membrane protein. Membrane {ECO:0000250|UniProtKB:Q9NUM4};
CC       Lipid-anchor {ECO:0000250|UniProtKB:Q9NUM4}.
CC   -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC102965; AAI02966.1; -; mRNA.
DR   RefSeq; NP_001029509.1; NM_001034337.1.
DR   RefSeq; XP_015323767.1; XM_015468281.1.
DR   RefSeq; XP_015323769.1; XM_015468283.1.
DR   AlphaFoldDB; Q3ZC25; -.
DR   STRING; 9913.ENSBTAP00000026319; -.
DR   PaxDb; Q3ZC25; -.
DR   Ensembl; ENSBTAT00000026319; ENSBTAP00000026319; ENSBTAG00000019750.
DR   GeneID; 508903; -.
DR   KEGG; bta:508903; -.
DR   CTD; 54664; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019750; -.
DR   VGNC; VGNC:35945; TMEM106B.
DR   eggNOG; ENOG502QQRZ; Eukaryota.
DR   GeneTree; ENSGT00940000158360; -.
DR   HOGENOM; CLU_089337_2_0_1; -.
DR   InParanoid; Q3ZC25; -.
DR   OMA; QTSQERY; -.
DR   OrthoDB; 1175832at2759; -.
DR   TreeFam; TF328907; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000019750; Expressed in occipital lobe and 109 other tissues.
DR   ExpressionAtlas; Q3ZC25; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   GO; GO:0007041; P:lysosomal transport; IBA:GO_Central.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
DR   InterPro; IPR009790; TMEM106.
DR   PANTHER; PTHR28556; PTHR28556; 1.
DR   Pfam; PF07092; DUF1356; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Glycoprotein; Lipoprotein; Lysosome; Membrane; Myristate;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NUM4"
FT   CHAIN           2..275
FT                   /note="Transmembrane protein 106B"
FT                   /id="PRO_0000242649"
FT   TOPO_DOM        2..97
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..275
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NUM4"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   275 AA;  31213 MW;  33EE73967C885A43 CRC64;
     MGKSFSHLPL HSNKEDGYDG MTSTENIRNG LVNGEVHNED GRSGDVSQFP YVEFTGRDSV
     TCPTCQGTGR IPRGQENQLV ALIPYSDQRL RPRRTKLYVM ASVFVCLLLS GLAVFFLFPR
     SIDVKYIGVK SAYVSYDVQK RTIYLNITNT LNITNNNYYS VEVENITAQV QFSKTVIGKA
     RLNNITSIGP LDMKQIDYTV PTVIAEEMSY MFDFCTLLTI KVHNIVLMMQ VTVTTTYFGH
     SEQISQERYQ YVDCGRNTTY HLGQSEYLNV LQPQQ