T106C_MOUSE
ID T106C_MOUSE Reviewed; 260 AA.
AC Q80VP8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transmembrane protein 106C;
GN Name=Tmem106c; Synonyms=D15Ertd405e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Membrane
CC {ECO:0000250|UniProtKB:Q9BVX2}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q9BVX2}.
CC -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
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DR EMBL; AK134684; BAE22240.1; -; mRNA.
DR EMBL; BC046621; AAH46621.1; -; mRNA.
DR CCDS; CCDS27785.1; -.
DR RefSeq; NP_001239082.1; NM_001252153.1.
DR RefSeq; NP_958747.1; NM_201359.2.
DR RefSeq; XP_006521180.1; XM_006521117.1.
DR RefSeq; XP_006521182.1; XM_006521119.1.
DR RefSeq; XP_006521183.1; XM_006521120.3.
DR RefSeq; XP_006521184.1; XM_006521121.3.
DR RefSeq; XP_017172161.1; XM_017316672.1.
DR AlphaFoldDB; Q80VP8; -.
DR STRING; 10090.ENSMUSP00000069764; -.
DR GlyConnect; 2787; 3 N-Linked glycans (2 sites).
DR GlyGen; Q80VP8; 2 sites, 3 N-linked glycans (2 sites).
DR iPTMnet; Q80VP8; -.
DR PhosphoSitePlus; Q80VP8; -.
DR EPD; Q80VP8; -.
DR MaxQB; Q80VP8; -.
DR PaxDb; Q80VP8; -.
DR PeptideAtlas; Q80VP8; -.
DR PRIDE; Q80VP8; -.
DR ProteomicsDB; 254624; -.
DR Antibodypedia; 25478; 36 antibodies from 18 providers.
DR DNASU; 380967; -.
DR Ensembl; ENSMUST00000064200; ENSMUSP00000069764; ENSMUSG00000052369.
DR Ensembl; ENSMUST00000229428; ENSMUSP00000154819; ENSMUSG00000052369.
DR GeneID; 380967; -.
DR KEGG; mmu:380967; -.
DR UCSC; uc007xlm.2; mouse.
DR CTD; 79022; -.
DR MGI; MGI:1196384; Tmem106c.
DR VEuPathDB; HostDB:ENSMUSG00000052369; -.
DR eggNOG; ENOG502QQ43; Eukaryota.
DR GeneTree; ENSGT00940000161281; -.
DR HOGENOM; CLU_089337_0_0_1; -.
DR InParanoid; Q80VP8; -.
DR OMA; PYVYAFC; -.
DR OrthoDB; 1175832at2759; -.
DR PhylomeDB; Q80VP8; -.
DR TreeFam; TF328907; -.
DR BioGRID-ORCS; 380967; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem106c; mouse.
DR PRO; PR:Q80VP8; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q80VP8; protein.
DR Bgee; ENSMUSG00000052369; Expressed in retinal neural layer and 241 other tissues.
DR ExpressionAtlas; Q80VP8; baseline and differential.
DR Genevisible; Q80VP8; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR009790; TMEM106.
DR PANTHER; PTHR28556; PTHR28556; 1.
DR Pfam; PF07092; DUF1356; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Lipoprotein; Membrane; Myristate;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9BVX2"
FT CHAIN 2..260
FT /note="Transmembrane protein 106C"
FT /id="PRO_0000243901"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:Q9BVX2"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 260 AA; 28952 MW; 2DCA0BBFB4E884AB CRC64;
MGSQHSSALT FCQRKKDDNP EDLLADRDQE EAIAQFPYVE FTGRNSITCH TCQGAGYIPA
EQVNELVALI PHSDQRLRPQ RTKQYVLLSV LLCLLASGLV FFFLFPHSVL VDDNGIKVTK
VTFNEQDSLV VLDVTATLKI RNSNFYPVAV TNLFSQVQYM KAVVGSYTTT NVSLIAPRSE
HLVNFTVKAE VGGPSSYVYF YCTLPAIRVH NIVIFMRTSV KISYIGHISQ STLETQHYVD
CGVNSTAAQS LFLVPRGPHL
