ID   T106C_RAT               Reviewed;         260 AA.
AC   Q5RJK0;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Transmembrane protein 106C;
GN   Name=Tmem106c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q9BVX2}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q9BVX2}.
CC   -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
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DR   EMBL; BC086606; AAH86606.1; -; mRNA.
DR   RefSeq; NP_001008359.1; NM_001008358.1.
DR   RefSeq; XP_006242388.1; XM_006242326.3.
DR   RefSeq; XP_017450377.1; XM_017594888.1.
DR   AlphaFoldDB; Q5RJK0; -.
DR   STRING; 10116.ENSRNOP00000011638; -.
DR   GlyGen; Q5RJK0; 1 site.
DR   PaxDb; Q5RJK0; -.
DR   PRIDE; Q5RJK0; -.
DR   Ensembl; ENSRNOT00000090079; ENSRNOP00000071424; ENSRNOG00000053269.
DR   GeneID; 315286; -.
DR   KEGG; rno:315286; -.
DR   UCSC; RGD:1311532; rat.
DR   CTD; 79022; -.
DR   RGD; 1311532; Tmem106c.
DR   eggNOG; ENOG502QQ43; Eukaryota.
DR   GeneTree; ENSGT00940000161281; -.
DR   HOGENOM; CLU_089337_0_0_1; -.
DR   InParanoid; Q5RJK0; -.
DR   OMA; PYVYAFC; -.
DR   OrthoDB; 1175832at2759; -.
DR   PhylomeDB; Q5RJK0; -.
DR   TreeFam; TF328907; -.
DR   PRO; PR:Q5RJK0; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000053269; Expressed in heart and 20 other tissues.
DR   Genevisible; Q5RJK0; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009790; TMEM106.
DR   PANTHER; PTHR28556; PTHR28556; 1.
DR   Pfam; PF07092; DUF1356; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Lipoprotein; Membrane; Myristate;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVX2"
FT   CHAIN           2..260
FT                   /note="Transmembrane protein 106C"
FT                   /id="PRO_0000243902"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BVX2"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  28908 MW;  AE3F3E78DA033E85 CRC64;
     MGSQHSSALT FCQRKKDDNP EDLLAERDQE EAIAQFPYVE FTGRNSITCH TCQGAGYIPE
     EQVNKLVALI PHSDQRLRPQ RTKQYVLLSV LLCLLASGLV FFFLFPHSVL VDDNGIRVSN
     VTFNKQDSLV VLDVTATLKI RNSNFYPVAV TNLFSQVQYM KAVVGSYTAA NVSLIPPRSE
     HLVNFTVKAE VGGPSSYVYF YCTLPAILVH NIVIFMRTSV QISYIGHTSQ STLEAQHNVD
     CGENSTAVQS LLLVPWGPHL